Validation of a frailty index in older cancer patients with solid tumours

BMC Cancer
A L McCarthyR E Hubbard

Abstract

Frailty is an indicator of physiological reserve in older people. In non-cancer settings, frailty indices are reliable predictors of adverse health outcomes. The aims of this study were to 1) derive and validate a frailty index (FI) from comprehensive geriatric assessment (CGA) data obtained in the solid tumour chemotherapy setting, and 2) to explore whether the FI-CGA could predict chemotherapy decisions and survival in older cancer patients with solid tumours. Prospective cohort study of a consecutive series sample of 175 cancer patients aged 65 and older with solid tumours. A frailty index was calculated using an accumulated deficits model, coding items from the comprehensive geriatric assessment tool administered prior to chemotherapy decision-making. The domains of physical and cognitive functioning, nutrition, mood, basic and instrumental activities of daily living, and comorbidities were incorporated as deficits into the model. The FI-CGA had a right-skewed distribution, with median (interquartile range) of 0.27 (0.21-0.39). The 99% limit to deficit accumulation was below the theoretical maximum of 1.0, at 0.75. The FI-CGA was significantly related (p < 0.001) to vulnerability as assessed by the Vulnerable Elders Survey-...Continue Reading

References

Mar 16, 2000·Palliative Medicine·F Kai-hoi SzeJ Woo
Dec 29, 2000·Archives of Physical Medicine and Rehabilitation·M E Cohen, R J Marino
Feb 15, 2002·Journal of the American Geriatrics Society·D SalibaN S Wenger
May 3, 2003·Journal of Clinical Epidemiology·Vincent de GrootLex M Bouter
Jun 14, 2003·TheScientificWorldJournal·A B MitnitskiK Rockwood
Sep 1, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Kenneth RockwoodArnold Mitnitski
Apr 20, 2006·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Elisabeth IsenringBogda Koczwara
Jul 20, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kenneth Rockwood, Arnold Mitnitski
Sep 25, 2008·Journal of the American Geriatrics Society·Fabio SalviPaolo Dessì-Fulgheri
Oct 2, 2008·BMC Geriatrics·Samuel D SearleKenneth Rockwood
Mar 24, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrea LucianiPaolo Foa
Aug 4, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Arti HurriaWilliam P Tew
Mar 7, 2015·Heart, Lung & Circulation·R E Hubbard, D A Story
Apr 19, 2015·BMC Geriatrics·Ruth E HubbardKenneth Rockwood
Sep 5, 2015·Australasian Journal on Ageing·Ruth E HubbardDavid W Johnson
May 18, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Arti HurriaWilliam P Tew
May 23, 2017·Age and Ageing·Ruth E HubbardKenneth Rockwood

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Citations

Oct 4, 2020·Archives of Gynecology and Obstetrics·Elisabeth ReiserChristoph Grimm
Aug 4, 2020·Annals of Geriatric Medicine and Research·Chang Won WonMiji Kim
Feb 20, 2020·Journal of General Internal Medicine·Sandra M ShiDae Hyun Kim
Oct 14, 2020·Journal of Geriatric Oncology·Henry ChanSharon Jackson
Sep 7, 2021·Frontiers in Medicine·Eron G ManusovSarah Williams-Blangero

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Methods Mentioned

BETA
hormone modification

Software Mentioned

Statistical Package for the Social Sciences

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