Validation of a low-cost, liquid-based screening method for cervical intraepithelial neoplasia

American Journal of Obstetrics and Gynecology
Judy M LeeDouglas P Clark

Abstract

The objective of the study was to validate a low-cost, liquid-based method for cervical cancer screening. We conducted a retrospective, split-sample comparison of 300 liquid-based cervical cytology samples from a group of 150 human immunodeficiency virus-seropositive women and 150 women from low-risk general gynecology clinics whose specimens were screened via standard liquid-based methodology as part of routine care. Residual samples from each specimen were used to prepare a slide using a novel, inexpensive manual membrane method of liquid-based cytology. These slides were screened by a cytotechnologist and abnormal cases were reviewed by a pathologist. Final diagnoses from the manual membrane method of liquid-based cytology slides were compared with the original diagnoses and available cervical biopsy data. There was good overall agreement between the manual membrane method of liquid-based cytology and original cytology diagnoses (76.3% agreement; kappa = 0.52, 95% confidence interval 0.44 to 0.59). Using available biopsy data to determine the accuracy of each method to identify high-grade squamous intraepithelial lesions, the manual membrane method of liquid-based cytology method was found to have a higher sensitivity (71.4%...Continue Reading

References

Jun 26, 2003·The Journal of Infectious Diseases·Paula SchumanUNKNOWN HIV Epidemiology Research Study (HERS) Group
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
Jul 21, 2005·The Australian & New Zealand Journal of Obstetrics & Gynaecology·A Munro Neville, Michael A Quinn
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Nov 18, 2005·The New England Journal of Medicine·Sue J GoldieUNKNOWN Alliance for Cervical Cancer Prevention Cost Working Group

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Citations

Jan 1, 2014·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Ling ZhangSiping Chen
Oct 27, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·N M NandiniMurali Dhar
Feb 27, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Najla Yussuf MoosaAsima Javid

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