Validation of a method to screen for pulmonary hypertension in advanced idiopathic pulmonary fibrosis

Chest
David A ZismanSteven D Nathan

Abstract

We have developed a method to screen for pulmonary hypertension (PH) in idiopathic pulmonary fibrosis (IPF) patients, based on a formula to predict mean pulmonary artery pressure (MPAP) from standard lung function measurements. The objective of this study was to validate this method in a separate group of IPF patients. Cross-sectional study of 60 IPF patients from two institutions. The accuracy of the MPAP estimation was assessed by examining the correlation between the predicted and measured MPAPs and the magnitude of the estimation error. The discriminatory ability of the method for PH was assessed using the area under the receiver operating characteristic curve (AUC). There was strong correlation in the expected direction between the predicted and measured MPAPs (r = 0.72; p < 0.0001). The estimated MPAP was within 5 mm Hg of the measured MPAP 72% of the time. The AUC for predicting PH was 0.85, and did not differ by institution. A formula-predicted MPAP > 21 mm Hg was associated with a sensitivity, specificity, positive predictive value, and negative predictive value of 95%, 58%, 51%, and 96%, respectively, for PH defined as MPAP from right-heart catheterization > 25 mm Hg. A prediction formula for MPAP using standard lung ...Continue Reading

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Jun 25, 2009·Current Opinion in Pulmonary Medicine·Stephen K Frankel, Marvin I Schwarz
Oct 16, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jeffrey J SwigrisSteven D Nathan
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Jun 16, 2021·Current Opinion in Pulmonary Medicine·Jürgen Behr, Steven D Nathan

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