Validation of a new automated method for analysis of gated-SPECT images

Clinical Physiology and Functional Imaging
Milan LomskyLars Edenbrandt

Abstract

We recently presented a new method for quantification of CArdiac FUnction--denoted CAFU--as the first step in the development of an automated method for integrated interpretation of gated myocardial perfusion single photon emission computed tomography (SPECT) images. The aim of this study was to validate CAFU in the assessment of global and regional function of the left ventricle. Quantitative gated-SPECT (QGS), the most widely used software package for quantification of gated-SPECT images, was used as reference method for the measurements of ejection fraction (EF) and ventricular volumes, and visual analysis by an experienced physician was used as reference method for the measurements of regional wall motion and thickening. Two different groups of consecutive patients referred for myocardial perfusion scintigraphy were studied. Global function was evaluated in 316 patients and regional function in 49 other patients. The studies were performed using a 2-day stress/rest 99 m-Tc-sestamibi protocol. A good correlation was found between EF values from QGS and CAFU (EF CAFU = 0.84 EF QGS + 13, r = 0.94), but CAFU values were on average 4 EF points higher than QGS values. With CAFU the segments with normal thickening according to the...Continue Reading

References

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Jun 24, 2005·Clinical Physiology and Functional Imaging·Milan LomskyLars Edenbrandt

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Citations

May 21, 2008·European Journal of Nuclear Medicine and Molecular Imaging·K TägilL Edenbrandt
Dec 21, 2012·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Andrei TodicaM Hacker
Jan 21, 2014·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Lena JohanssonElin Trägårdh
Apr 9, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Milan LomskyLars Edenbrandt
Jul 1, 2008·The International Journal of Cardiovascular Imaging·K TägilL Edenbrandt
Feb 11, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Kenichi NakajimaErnest V Garcia
Jun 13, 2015·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Andrei TodicaGuido Böning
Apr 7, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Kenichi NakajimaLars Edenbrandt
Apr 8, 2011·Clinical Physiology and Functional Imaging·Peter GjertssonLars Edenbrandt
Sep 28, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Kenichi NakajimaLars Edenbrandt
Oct 12, 2018·Annals of Nuclear Medicine·Takayuki ShibutaniSeigo Kinuya

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