PMID: 10517648Oct 12, 1999Paper

Validation of a noninvasive measure of local myocardial repolarization in a conscious human model: adaptation of repolarization to changes in rate

Journal of Cardiovascular Electrophysiology
S D LeeD Newman

Abstract

A commercial pacemaker sensor measure of the unipolar endocardial stimulus to T wave interval may accurately reflect changes in the monophasic action potential duration at 90% repolarization (APD90). This sensor system was used to study the kinetics of adaptation of repolarization duration to changes in heart rate in humans. Patients were studied using an external pacemaker capable of displaying all stimulus to T wave intervals for each paced beat. Right ventricular stimulation was delivered via the pacemaker and compared simultaneously to APD90. Steady-state pacing was simulated by 60 seconds of pacing at cycle lengths (CLs) 350 to 700 msec. Adaptation to a new ventricular rate was analyzed with a sudden 200-msec decrease in CL. The relation between repolarization measure and steady-state CL (n = 16) was linear with a slope of 0.16 and 0.19 for APD90 and stimulus to T wave interval, respectively (P = NS). The adaptation of both repolarization measures to a sudden change in rate were best modeled by a biexponential function. Stimulus to T wave interval exhibited a parallel course to APD90, and an analysis of normalized differences between APD90 and stimulus to T wave interval followed an approximately normal distribution, with ...Continue Reading

References

May 1, 1991·Progress in Cardiovascular Diseases·M R Franz
Jun 1, 1988·Pacing and Clinical Electrophysiology : PACE·M W BaigE J Perrins
Jan 1, 1986·European Heart Journal·M VerstraeteP Sleight
Mar 1, 1985·Journal of the American College of Cardiology·S Ahnve
Sep 1, 1994·Pacing and Clinical Electrophysiology : PACE·J VainerH J Wellens
Oct 1, 1993·Canadian Journal of Physiology and Pharmacology·D NewmanR Feder-Elituv
Apr 1, 1994·British Heart Journal·A MurrayR W Campbell
Aug 26, 1993·The American Journal of Cardiology·C Funck-Brentano, P Jaillon
Mar 15, 1997·The American Journal of Cardiology·M Malik, A J Camm
Dec 5, 1997·The American Journal of Cardiology·M C de BruyneD E Grobbee
Apr 16, 1998·Medical & Biological Engineering & Computing·D R DickensonG N Beatch

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Citations

Jul 13, 2004·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Dayimi KayaCetin Dincel
Jul 13, 2004·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Christopher C E LangAndrew D Flapan

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