Validation of a protocol for manual segmentation of the thalamus on magnetic resonance imaging scans

Psychiatry Research
Brian D PowerJeffrey Chee Leong Looi

Abstract

We present a validated protocol for manual segmentation of the thalamus on T1-weighted magnetic resonance imaging (MRI) scans using brain image analysis software. The MRI scans of five normal control subjects were randomly selected from a larger cohort recruited from Lund University Hospital and Landskrona Hospital, Sweden. MRIs were performed using a 3.0T Philips MR scanner, with an eight-channel head coil, and high resolution images were acquired using a T1-weighted turbo field echo (T1 TFE) pulse sequence, with resulting voxel size 1×1×1 mm3. Manual segmentation of the left and right thalami and volume measurement was performed on 28-30 contiguous coronal slices, using ANALYZE 11.0 software. Reliability of image analysis was performed by measuring intra-class correlations between initial segmentation and random repeated segmentation of the left and right thalami (in total 10 thalami for segmentation); inter-rater reliability was measured using volumes obtained by two other experienced tracers. Intra-class correlations for two independent raters were 0.95 and 0.98; inter-class correlations between the expert rater and two independent raters were 0.92 and 0.98. We anticipate that mapping thalamic morphology in various neuropsy...Continue Reading

References

Jan 1, 1991·Biological Psychiatry·T L JerniganJ R Hesselink
May 1, 1995·The American Journal of Psychiatry·M FlaumN C Andreasen
Feb 1, 1996·The American Journal of Psychiatry·M S BuchsbaumW E Bunney
Jan 4, 2001·The American Journal of Psychiatry·U EttingerT Sharma
Feb 13, 2001·Biological Psychiatry·L C Konick, L Friedman
Jul 25, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Murad AtmacaA Kursad Poyraz
Jan 31, 2007·Proceedings of the National Academy of Sciences of the United States of America·Karl D MurrayEdward G Jones
Jun 15, 2007·Archives of Neurology·Valerie A CardenasColin Studholme
Apr 17, 2008·BMC Neurology·Martin J McKeownXuemei Huang
Jul 12, 2008·Dementia and Geriatric Cognitive Disorders·Tiffany W ChowSandra E Black
Jul 29, 2008·Psychiatry Research·Jeffrey Chee Leong LooiLars-Olof Wahlund
Nov 22, 2008·Brain : a Journal of Neurology·L W de JongJ van der Grond
Mar 1, 2011·NeuroImage·Brian PatenaudeMark Jenkinson
Jun 15, 2011·Parkinsonism & Related Disorders·Jennifer L WhitwellKeith A Josephs
Oct 18, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ming-Ying DuQi-Yong Gong
Nov 26, 2011·The British Journal of Psychiatry : the Journal of Mental Science·Joost JanssenManuel Desco
Sep 20, 2012·The Australian and New Zealand Journal of Psychiatry·Jeffrey C L LooiDennis Velakoulis
Oct 23, 2012·Journal of Neurology, Neurosurgery, and Psychiatry·Grace J LeeJohn M Ringman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cajal Bodies & Gems

Cajal bodies or coiled bodies are dense foci of coilin protein. Gemini of Cajal bodies, or gems, are microscopically similar to Cajal bodies. It is believed that Cajal bodies play important roles in RNA processing while gems assist the Cajal bodies. Find the latest research on Cajal bodies and gems here.