Validation of a test model of induced dysmenorrhea

Acta Obstetricia Et Gynecologica Scandinavica
Ragner LiedmanM Akerlund

Abstract

The myometrial hyperactivity and reduced uterine blood flow of primary dysmenorrhea is to a large extent caused by increased vasopressin secretion. A new therapeutic approach for this condition is to develop antagonists of uterine vasopressin V1a receptors. We studied a test model of vasopressin-induced dysmenorrhea in healthy, sterilized women and compared responses against those in dysmenorrheic subjects. Eight women with primary dysmenorrhea and eight sterilized, healthy women participated in recordings of intrauterine pressure and experienced pain on days 1-2 of two menstruations. We tried to identify biochemical markers in plasma of uterine ischemia. Furthermore, the effects of repeated bolus injections of 10 pmol/kg b w of vasopressin or placebo on these parameters were assessed. The vasopressin injections caused statistically significant increases in the area under the intrauterine pressure curve (AUC) in both healthy volunteers and patients with dysmenorrhea, the overall responses being greater in healthy volunteers. The experienced pain measured by visual analog scale in individual dysmenorrheic subjects tended to show higher maximal post-dose scores for the vasopressin injections than for placebo. Maximum visual analo...Continue Reading

Citations

Feb 24, 2009·Primary Care·Cathleen Morrow, Elizabeth H Naumburg
Oct 7, 2008·The Journal of Obstetrics and Gynaecology Research·Atsuko OyaToshihiko Hanawa
May 19, 2006·Expert Opinion on Therapeutic Targets·Mats Akerlund
Apr 7, 2009·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ragner LiedmanMats Akerlund
Dec 29, 2007·Paediatric Drugs·Linda French
Apr 27, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Baoying FengDongping Huang

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