Validation of Alternative Methods for Detecting Meibomian Gland Dropout Without an Infrared Light System: Red Filter for Simple and Effective Meibography

Cornea
Sang-Mok LeeHo Sik Hwang

Abstract

To evaluate the validity and reliability of alternative methods for evaluating meibomian gland (MG) dropout without using an infrared light system: red-filtered or isolated red-channel images (RCIs) of the everted eyelid. We evaluated MG dropout in the everted upper and lower eyelids of 125 eyes of 64 patients with good-quality infrared meibography images (IMIs) and color digital photographs with and without a red filter. Red-filtered images (RFIs) were converted to black and white and adjusted for contrast/brightness [adjusted red-filtered images (aRFIs)]. RCIs were computationally isolated from color digital photographs obtained without a red filter. After randomization, the total meiboscore (0-6) was evaluated by 2 independent evaluators (interobserver reliability) masked to the image origin, and again after a 30-day interval (intraobserver reliability). The meiboscores evaluated using the RFI, aRFI, and RCI were strongly positively correlated with those evaluated using the IMI (RFI: ρ = 0.788; aRFI: ρ = 0.735; RCI: ρ = 0.630; all P < 0.001, Spearman correlation analysis). Linear-weighted κ-values (κw) showed substantial agreement between the RFI and IMI (κw = 0.676, 95% CI = 0.594-0.759). The RFI had substantial intraobserv...Continue Reading

References

Apr 1, 1994·Archives of Ophthalmology·W D MathersR Verdick
Apr 15, 2005·Cornea·Jason J NicholsKelly K Nichols
Sep 12, 2009·Ophthalmology·Reiko AritaShiro Amano
Apr 1, 2011·Investigative Ophthalmology & Visual Science·Alan TomlinsonMurat Dogru
Apr 14, 2012·Investigative Ophthalmology & Visual Science·Daniel R PowellKelly K Nichols
Jul 25, 2017·The Ocular Surface·Jennifer P CraigFiona Stapleton
Jul 25, 2017·The Ocular Surface·James S WolffsohnJennifer P Craig

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