Validation of Chronic Restraint Stress Model in Young Adult Rats for the Study of Depression Using Longitudinal Multimodal MR Imaging.

ENeuro
Bhedita Jaya SeewooJennifer Rodger

Abstract

Prior research suggests that the neurobiological underpinnings of depression include aberrant brain functional connectivity, neurometabolite levels, and hippocampal volume. Chronic restraint stress (CRS) depression model in rats has been shown to elicit behavioral, gene expression, protein, functional connectivity, and hippocampal volume changes similar to those in human depression. However, no study to date has examined the association between behavioral changes and brain changes within the same animals. This study specifically addressed the correlation between the outcomes of behavioral tests and multiple 9.4 T magnetic resonance imaging (MRI) modalities in the CRS model using data collected longitudinally in the same animals. CRS involved placing young adult male Sprague Dawley rats in individual transparent tubes for 2.5 h daily over 13 d. Elevated plus maze (EPM) and forced swim tests (FSTs) confirmed the presence of anxiety-like and depression-like behaviors, respectively, postrestraint. Resting-state functional MRI (rs-fMRI) data revealed hypoconnectivity within the salience and interoceptive networks and hyperconnectivity of several brain regions to the cingulate cortex. Proton magnetic resonance spectroscopy revealed d...Continue Reading

Citations

Feb 23, 2021·Frontiers in Psychiatry·Bryan W Jenkins, Jibran Y Khokhar
May 15, 2021·Frontiers in Psychiatry·Ajay SarawagiAnant Bahadur Patel

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Methods Mentioned

BETA
sedation
proton magnetic resonance

Software Mentioned

FLIRT ( Linear Image Registration Tool
FEAT
LCModel
NifTI
LCModel ( Linear Combination of Model
FSL
MELODIC
RStudio
QUIT QUantitative Imaging
ParaVision

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