Validation of claims-based algorithms for pulmonary arterial hypertension

Pulmonary Circulation
Ravikanth PapaniAlexander G Duarte

Abstract

Administrative claims studies do not adequately distinguish pulmonary arterial hypertension (PAH) from other forms of pulmonary hypertension (PH). Our aim is to develop and validate a set of algorithms using International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes and electronic medical records (EMR), to identify patients with PAH. From January 2012 to August 2015, the EMRs of patients with ICD-9-CM codes for PH with an outpatient visit at the University of Texas Medical Branch were reviewed. Patients were divided into PAH or non-PAH groups according to EMR encounter diagnosis. Patient demographics, echocardiography, right heart catheterization (RHC) results, and PAH-specific therapies were assessed. RHC measurements were reviewed to categorize cases as hemodynamically determined PAH or not PAH. Weighted sensitivity, specificity, and positive and negative predictive values were calculated for the developed algorithms. A logistic regression analysis was conducted to determine how well the algorithms performed. External validation was performed at the University of Virginia Health System. The cohort for the development algorithms consisted of 683 patients with PH, PAH group (n = 191) and no...Continue Reading

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Citations

Jul 4, 2019·BMC Medical Informatics and Decision Making·Saeed Al-AzaziLisa M Lix
Mar 14, 2019·Annals of the American Thoracic Society·Stephen C MathaiCorey E Ventetuolo
Aug 24, 2019·Therapeutic Advances in Respiratory Disease·Michael HalankIoana R Preston
Feb 24, 2021·Therapeutic Advances in Respiratory Disease·Fernando ExpostoAmélie Beaudet
Feb 20, 2019·The American Journal of Cardiology·Nathaniel R SmilowitzJeffrey S Berger

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