Validation of contemporary guidelines for bone scintigraphy in prostate cancer staging: A prospective study in patients undergoing radical prostatectomy.

Scandinavian Journal of Urology
Helle Damgaard ZachoLars J Petersen

Abstract

The aim of this study was to evaluate, using international urology and oncology guidelines, the criteria for performing bone scintigraphy (BS) in patients with newly diagnosed prostate cancer in a prospective setting with 2 years of follow-up after prostatectomy. In a prospective setting, criteria from European and US urology and oncology guidelines were evaluated in 220 unselected patients with BS performed as a routine investigation before radical prostatectomy. A prostate-specific antigen level of 0.1 ng/ml or lower after surgery was considered successful and was used as a measure of true-negative BS. Overall, 200 out of 220 patients (91%) experienced successful radical prostatectomy at 6 months, with a 2 year success rate of 83%. The proportion of redundant BS ranged from 56% to 89% among the guidelines, whereas the outcome after radical prostatectomy was 93% within 6 months after surgery and 86-89% after 2 years of follow-up, without significant differences among guideline recommendations. The guidelines from the American Urological Association and the criteria recently published by the present group proposed the largest proportion of redundant BS without compromising patient-related outcome.

References

May 19, 2007·The Journal of Urology·Ian ThompsonUNKNOWN AUA Prostate Cancer Clinical Guideline Update Panel
Apr 12, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lowell E SchnipperDana S Wollins
Sep 8, 2012·Journal of the National Comprehensive Cancer Network : JNCCN·James L MohlerDorothy A Shead
Nov 12, 2013·European Urology·Axel HeidenreichUNKNOWN European Association of Urology
Nov 13, 2013·Clinical Nuclear Medicine·Helle Damgaard ZachoLars J Petersen
Dec 11, 2013·European Urology·Axel HeidenreichUNKNOWN European Association of Urology

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Citations

Feb 1, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Christian UprimnyIrene Johanna Virgolini

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