Validation of Heel Stick Microsampling To Optimize Micafungin Doses in Neonates and Young Infants

Antimicrobial Agents and Chemotherapy
Cinzia AuritiManjunath P Pai

Abstract

Major gaps exist in our knowledge of antimicrobial pharmacokinetics in critically ill neonates and infants that require validated microsampling and bioanalysis methods to support therapeutic drug monitoring. We compared serially collected intravenous (i.v.) and heel stick capillary (HSC)-sampled plasma concentrations of micafungin (8 mg/kg) in eight infants born preterm with systemic candidiasis. The mean (standard deviation) micafungin area under the plasma concentration-time curve to infinity (AUCinf) was 316 (65.0) h · mg/liter based on HSC concentrations that strongly correlated (R2 = 0.92) with i.v. values to support dose adjustment.

References

Jan 7, 2006·Pediatrics·Daniel K BenjaminUNKNOWN National Institute of Child Health and Human Development Neonatal Research Network
Jun 18, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Jens Martens-LobenhofferStefanie M Bode-Böger
Jan 4, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·W W HopeUNKNOWN ESCMID Fungal Infection Study Group
Sep 28, 2017·Current Pharmaceutical Design·P MianB C P Koch
May 11, 2018·British Journal of Clinical Pharmacology·S LerouxUNKNOWN FP7 TINN (Treat Infections in NeoNates) consortium

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Citations

Sep 11, 2019·Journal of Clinical Pharmacology·Solange Corriol-Rohou, S Y Amy Cheung
Feb 10, 2021·Antimicrobial Agents and Chemotherapy·Cinzia AuritiManjunath P Pai

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