Validation of high-risk HPV tests for primary cervical screening

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Chris J L M MeijerPeter J F Snijders

Abstract

From a clinical point of view, testing for a broad spectrum of high-risk human papillomavirus (hrHPV) is only useful when a positive hrHPV test result is informative about the presence of high-grade cervical intraepithelial neoplasia or cervical cancer (CIN 2 or worse). Two hrHPV tests, i.e. HC2 and GP5+/6+, have shown in large clinical trials that they perform better in the detection of CIN 2+/CIN 3+ lesions than cytology and thus have been clinically validated. Consequently these tests are now considered as alternative screening tools for cytology in cervical screening. Candidate hrHPV tests to be used for cervical screening should have a similar balance between sensitivity and specificity for CIN 2+ lesions as these two clinically validated hrHPV tests in order to prevent redundant or excessive follow-up procedures for women with transient hrHPV infections or hrHPV-positive women without cervical lesions. The data from these large prospective clinical studies can be used to set standards for the clinical performance and characteristics of the candidate hrHPV test. To prevent costly validation trajects of candidate hrHPV tests and based on the available data from large clinical studies we demonstrate how guidelines for hrHPV ...Continue Reading

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Citations

Sep 2, 2011·Journal of Clinical Microbiology·D A M HeidemanP J F Snijders
Nov 15, 2011·Virology Journal·Franca PirasPaola Sirigu
Dec 24, 2011·Virology Journal·Ramona Gabriela UrsuLuminiţa-Smaranda Iancu
Jan 26, 2016·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·A T HesselinkD A M Heideman
Apr 8, 2011·Diagnostic Cytopathology·Ted E Schutzbank, Christine C Ginocchio
Jun 18, 2010·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Peter J F SnijdersChris J L M Meijer
Jun 18, 2010·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Louise T ChowBettie M Steinberg
Sep 4, 2013·Cytopathology : Official Journal of the British Society for Clinical Cytology·H A Cubie, K Cuschieri
Jan 3, 2014·BioMed Research International·Maria Lina TorneselloFranco M Buonaguro
Aug 11, 2012·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Luisa BarzonGiorgio Palù
Mar 27, 2012·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Maaike G DijkstraChris J L M Meijer
Aug 12, 2014·BMC Cancer·Raquel IbáñezSilvia de Sanjosé
Nov 30, 2016·BMC Cancer·Cornelis Johannes Jacobus HuijsmansAdrianus Johannes Christiaan van den Brule
May 28, 2014·Revista Da Sociedade Brasileira De Medicina Tropical·Livia Bravo MaiaPaulo Gonçalves de Oliveira
Jun 29, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Matthias JentschkePeter Hillemanns
Oct 20, 2010·Expert Review of Anti-infective Therapy·Mario Poljak, Boštjan J Kocjan
Dec 7, 2013·Expert Review of Anticancer Therapy·Remko P BosgraafWillem J G Melchers
Aug 24, 2012·Critical Reviews in Clinical Laboratory Sciences·Paul K S ChanJong Sup Park
Jun 21, 2020·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Anne J M LoonenAdriaan J C van den Brule
Sep 8, 2015·HIV Medicine·L B MaiaP G de Oliveira
Mar 30, 2018·PeerJ·Leonora Maciel de Souza ViannaAnamélia Lorenzetti Bocca
Feb 26, 2016·Clinical Microbiology Reviews·Eileen M Burd
Jan 22, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M G DijkstraC J L M Meijer

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