Validation of inflammatory genetic variants associated with long-term cancer related fatigue in a large breast cancer cohort

Brain, Behavior, and Immunity
T KühlJ Chang-Claude

Abstract

Studies to date have reported several associations between single nucleotide polymorphisms (SNPs) and cancer related fatigue (CRF), but have been limited by small sample sizes, missing adjustment for relevant covariates or multiple testing, as well as varying CRF definitions, i.e. time and method of assessment. This study aimed to validate previously reported associations using the largest independent breast cancer sample to date and to evaluate further functional cytokine variants in relation to total CRF and all relevant CRF subdomains (physical, cognitive, and affective CRF). 45 candidate SNPs in inflammatory pathway genes were selected based on previous reports (16 SNPs) or regulatory function (29 SNPs). Breast cancer patients recruited between 2002 and 2005 provided information on CRF at first follow-up (FU1) (N = 1389) and second follow-up (FU2) (N = 950), a median of 6.2 years and 11.7 years respectively after diagnosis. SNP associations were assessed using linear regression models on CRF scores separately for FU1 and FU2. Additionally, patients with persistent fatigue (fatigued at both time-points) were compared to those never fatigued using logistic regression models (N = 684). All analyses were adjusted for relevant c...Continue Reading

Citations

Aug 1, 2019·Reviews on Recent Clinical Trials·Mara MirandolaAlberto Zaniboni
Jul 4, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Julia E InglisLuke J Peppone
Mar 6, 2021·The Breast : Official Journal of the European Society of Mastology·T MaurerJ Chang-Claude

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