Validation of International Society of Urological Pathology (ISUP) grading for prostatic adenocarcinoma in thin core biopsies using TROG 03.04 'RADAR' trial clinical data

Pathology
Brett DelahuntJames W Denham

Abstract

In 2014 a consensus conference convened by the International Society of Urological Pathology (ISUP) adopted amendments to the criteria for Gleason grading and scoring (GS) for prostatic adenocarcinoma. The meeting defined a modified grading system based on 5 grading categories (grade 1, GS 3+3; grade 2, GS 3+4; grade 3, GS 4+3; grade 4, GS 8; grade 5, GS 9-10). In this study we have evaluated the prognostic significance of ISUP grading in 496 patients enrolled in the TROG 03.04 RADAR Trial. There were 19 grade 1, 118 grade 2, 193 grade 3, 88 grade 4 and 79 grade 5 tumours in the series, with follow-up for a minimum of 6.5 years. On follow-up 76 patients experienced distant progression of disease, 171 prostate specific antigen (PSA) progression and 39 prostate cancer deaths. In contrast to the 2005 modified Gleason system (MGS), the hazards of the distant and PSA progression endpoints, relative to grade 2, were significantly greater for grades 3, 4 and 5 of the 2014 ISUP grading scheme. Comparison of predictive ability utilising Harrell's concordance index, showed 2014 ISUP grading to significantly out-perform 2005 MGS grading for each of the three clinical endpoints.

References

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Citations

Aug 13, 2015·Histopathology·Brett DelahuntJohn R Srigley
Mar 24, 2016·Expert Review of Anticancer Therapy·Rodolfo MontironiMarina Scarpelli
May 7, 2016·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Lars EgevadHemamali Samaratunga
Mar 30, 2016·The American Journal of Surgical Pathology·Lars EgevadJohn R Srigley
Jul 15, 2016·Scandinavian Journal of Urology·Hemamali SamaratungaLars Egevad
Mar 16, 2017·Journal of Clinical Pathology·Joe YeongLi Yan Khor
Aug 8, 2017·Asian Journal of Andrology·Silvia GasparriniRodolfo Montironi
Dec 6, 2018·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Brett DelahuntHemamali Samaratunga
Mar 14, 2019·Archives of Pathology & Laboratory Medicine·Gladell P PanerMahul B Amin
Jan 11, 2017·Prostate Cancer and Prostatic Diseases·R MathieuS F Shariat
May 16, 2019·Journal of the National Comprehensive Cancer Network : JNCCN·James L MohlerDeborah A Freedman-Cass
Feb 27, 2020·Archives of Pathology & Laboratory Medicine·Travis Rice-StittChin-Lee Wu
Jan 31, 2017·Archives of Pathology & Laboratory Medicine·Jonathan I Epstein, Oleksandr N Kryvenko
Jan 31, 2017·Archives of Pathology & Laboratory Medicine·Brett DelahuntLars Egevad
Feb 9, 2017·International Journal of Urology : Official Journal of the Japanese Urological Association·Arnout R AlbertsMonique J Roobol
Apr 9, 2017·Cold Spring Harbor Perspectives in Medicine·Peter A Humphrey
Aug 12, 2017·BMC Cancer·K R BeckmannUNKNOWN South Australia Prostate Cancer Clinical Outcomes Collaborative
Jun 17, 2020·Virchows Archiv : an International Journal of Pathology·Lars EgevadMartin Eklund
Nov 19, 2020·BJU International·Lars EgevadHemamali Samaratunga
Jun 26, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jonathan TobyThomas P Shakespeare

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Methods Mentioned

BETA
biopsy
biopsies

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Stata

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