Validation of modified estimated glomerular filtration rate in chronic kidney disease patients

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
Ghulam Murtaza ShaikhMujahid Khalid Ali


To derive the ethnic factor and validate the modified estimated Glomerular Filtration Rate (eGFR) by Modification of Diet in Renal Disease (MDRD) equation for Chronic Kidney Disease (CKD) patients of Rawalpindi. Cross- sectional study. Armed Forces Institute of Pathology (AFIP), Rawalpindi, from July 2011 to July 2012. A total of 140 patients with CKD reporting to AFIP for GFR measurement by 99mTechnetium diethylenethiaminepenta-acetic acid (99mTc-DTPA) renal scan were consecutively inducted. Serum creatinine was measured by the Jaffe's assay on Beckman DxC 600 Analyzer prior to the renal scan. Ethnic factor for population of Rawalpindi with CKD was derived for the MDRD eGFR equation using 99mTc-DTPA renal scan by Gates method as the reference method. MDRD equation was modified by inclusion of the ethnic factor in it. Agreement between the reference GFR (rGFR) and the modified MDRD eGFR (mGFR) was assessed by applying paired samples t-test. Out of 140 patients of CKD, 99 (71%) were males and 41 (29%) females, with mean age of 55 ± 13.42 years. The mean values were 32.91 ± 14.96, 34.89 ± 16.45, 0.971 ± 0.20 and 33.87 ± 15.97 for rGFR, original eGFR, ethnic factor and mGFR respectively. The mGFR with new ethnic factor of 0.971 sh...Continue Reading

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