PMID: 3383621Jul 1, 1988Paper

Validation of morning dip of peak expiratory flow as an indicator of the severity of nocturnal asthma

Chest
V BelliaG Bonsignore

Abstract

Overnight falls in peak expiratory flow (PEF) (with the morning dip of the index) may be considered the hallmark of nocturnal asthma. To validate the morning dip a quantitative marker of the degree of nocturnal bronchoconstriction, the dip was measured in 11 subjects (six with a history consistent with nocturnal asthma) undergoing all-night monitoring of lower respiratory resistance by a double-catheter method. In six subjects, marked and recurrent increases in resistance were recorded, along with morning dips higher than 20 percent; however, on the following morning, only two of them reported having suffered significant breathlessness and wheeze. Peak and average values for resistance, as well as the duration for which resistance was increased, were closely correlated with the magnitude of morning dips. Therefore, unlike the subjective report, PEF may be considered a reliable quantitative indicator of nocturnal bronchoconstriction.

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Citations

Jan 1, 1996·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·J T Li, E J O'Connell
Aug 1, 1989·The American Review of Respiratory Disease·V BelliaG Bonsignore
Feb 1, 1991·The American Review of Respiratory Disease·J J QuackenbossM Krzyzanowski
Aug 27, 2014·Clinics in Chest Medicine·Wajahat H KhanCarolyn M D'Ambrosio
Apr 17, 2010·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Attilio L BonerSimon Godfrey
Jan 1, 1992·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·R H ZaragozaD L Bratton
Apr 17, 2008·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·John G MastronardeUNKNOWN American Lung Association Asthma Clinical Research Centers
Sep 22, 1998·Chest·P JainM Ahmad
Apr 11, 2001·Chest·F T LeoneUNKNOWN Asthma Clinical Research Network of the National Heart, Lung, and Blood Institute
Dec 26, 2001·The American Journal of Medicine·F Cibella, G Cuttitta
Aug 1, 1993·Current Problems in Pediatrics·L Smith
Apr 29, 1998·Clinics in Chest Medicine·C M D'Ambrosio, V Mohsenin
Jan 1, 1991·Pediatric Pulmonology·M D Lebowitz
Nov 14, 1997·Chronobiology International·N KazumaM Murata
Feb 1, 1994·American Journal of Respiratory and Critical Care Medicine·P L EnrightD W Cockroft
May 7, 2002·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Abraham B BohadanaDan B Teculescu

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