Validation of patient's self-reported social functioning as an independent prognostic factor for survival in metastatic colorectal cancer patients: results of an international study by the Chronotherapy Group of the European Organisation for Research and Treatment of Cancer

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Fabio EfficaceChronotherapy Group of the European Organisation for Research and Treatment of Cancer

Abstract

A recent study identified a prognostic model for survival in metastatic colorectal cancer patients which included WBC count, alkaline phosphatase (AP), number of metastatic sites, and patients' self-reported social functioning. The aim of this research is to validate this model on data from an independent sample. This validation study is based on a prospective randomized controlled trial in patients with metastatic colorectal cancer conducted by the European Organisation for Research and Treatment of Cancer (EORTC) Chronotherapy Group. Overall, 564 patients in 10 countries were enrolled. For the purpose of this independent validation, patients with health-related quality of life (HRQOL) baseline data were analyzed. HRQOL was assessed using the EORTC Quality of Life Questionnaire C30 (QLQ-C30). The Cox proportional hazards regression model was used for both univariate and multivariate analyses of survival. The previous model with an additional adjustment, by stratification for sex, was replicated and its parameters were confirmed to independently predict survival: WBC count with an hazard ratio (HR) of 1.31 (95% CI, 1.021 to 1.698; P = .034); AP with an HR of 1.53 (95% CI, 1.188 to 1.979; P = .001); number of sites involved with...Continue Reading

References

Dec 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A CoatesJ F Forbes
Jan 24, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D OsobaJ Pater
Mar 1, 2000·Statistics in Medicine·D G Altman, P Royston
Aug 10, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J A KramerR Paridaens
Nov 15, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A S CoatesA Goldhirsch
Mar 10, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A de GraeffJ A Winnubst
Jul 4, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R Schwarz, A Hinz
Jul 2, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·N R MaiseyD Cunningham
Feb 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D F RoychowdhuryA M Liepa
Apr 17, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David T EtonUNKNOWN Eastern Cooperative Oncology Group
Jul 12, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·V Chiarion-SileniUNKNOWN Italian Melanoma Intergroup (IMI)
Mar 31, 2004·International Journal of Radiation Oncology, Biology, Physics·Fu-Min FangChing-Yeh Hsiung
Apr 20, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F EfficaceUNKNOWN EORTC-BCG-IDBBC-NDDG
Aug 18, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Fabio EfficaceAndrew Bottomley
Oct 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pamela J GoodwinNicky Hood
Dec 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Volker ArndtHermann Brenner
Feb 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Fabio Efficace, Andrew Bottomley
Nov 22, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Fabio EfficaceClaus-Henning Köhne
Jan 25, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dominique DuboisChristine de la Loge
Apr 8, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·W YeoB Zee
Jul 11, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Volker ArndtHermann Brenner
Aug 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sylvie GiacchettiUNKNOWN European Organisation for Research and Treatment of Cancer Chronotherapy Group
Sep 14, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F EfficaceUNKNOWN EORTC Lung Cancer Group and Quality of Life Unit
Dec 21, 2006·JAMA : the Journal of the American Medical Association·Steven C Bergeson, John D Dean
Jan 30, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Carolyn C GotayFabio Efficace
Apr 1, 2008·Expert Review of Pharmacoeconomics & Outcomes Research·Me MauerC Gotay

❮ Previous
Next ❯

Citations

May 27, 2008·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·M E MauerC Coens
Jan 20, 2009·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Matthias Rose, Andrea Bezjak
Feb 23, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B CoudertUNKNOWN EORTC Chronotherapy Group
Feb 4, 2010·The American Journal of Chinese Medicine·Jian-Hui TianLin Wang
May 28, 2009·Cancer Research·Pasquale F InnominatoUNKNOWN Chronotherapy Group of the European Organization for Research and Treament of Cancer
Jul 27, 2011·Therapeutic Advances in Medical Oncology·David Osoba
Aug 12, 2009·Expert Opinion on Pharmacotherapy·Maurizio SalvatiAlessandro Frati
Dec 15, 2015·Journal of the National Cancer Institute·S Yousuf Zafar
Dec 27, 2013·International Journal of Surgical Oncology·Abhiram SharmaJohn R T Monson
Jun 11, 2014·Annals of Medicine·Pasquale F InnominatoFrancis A Lévi
Aug 30, 2008·Health and Quality of Life Outcomes·Kathleen J YostDee W West
Nov 6, 2010·MAbs·Janice M Reichert
Aug 5, 2011·Health and Quality of Life Outcomes·Donald P BraunEdgar D Staren
Apr 10, 2010·Journal of Oncology·Manmeet S Ahluwalia, Candece L Gladson
Nov 10, 2016·Expert Review of Pharmacoeconomics & Outcomes Research·Simon B ZeichnerDaniel A Goldstein
Dec 25, 2008·Expert Review of Anticancer Therapy·Patrick Y Wen
Jun 25, 2009·Current Opinion in Supportive and Palliative Care·Eduardo García Yanneo
Jun 30, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Tiffany T HuangPaul S Mischel
Mar 30, 2017·Pharmacological Reviews·Annabelle BallestaFrancis A Lévi
Sep 16, 2017·International Journal of Colorectal Disease·Dan AsplundEva Angenete
Aug 1, 2019·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Claudia RutherfordMadeleine King
Nov 28, 2009·Expert Review of Pharmacoeconomics & Outcomes Research·Catherine Legrand, Fabio Efficace
Jun 29, 2017·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Oxana PaleshPasquale F Innominato
Sep 19, 2012·European Journal of Haematology·Fabio EfficaceFranco Mandelli
Jan 15, 2013·Journal of Psychosocial Oncology·Adrian A KapteinHans Nortier
Jan 20, 2019·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Francesco CottoneFabio Efficace
Feb 13, 2017·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Dylan ZyllaPankaj Gupta
Nov 6, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Justin C BrownBlair T Johnson

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