Validation of Region of Interest Measurements for the Objective Assessment of Post-Contrast Enhancement of Renal Lesions on MRI.

The British Journal of Radiology
Ishaq Sulaiman Al SalmiAbdullah Alabousi

Abstract

The aim of this study was to validate the use of region of interest (ROI) measurements in MRI to objectively assess for enhancement in suspected solid renal masses and to determine a minimum threshold value for true enhancement. Contrast-enhanced renal MRI studies performed between January 2015 and December 2017 for patients with a known renal mass who had subsequent biopsy, or partial/radical nephrectomy were included. Two body imaging fellows independently measured the mean ROI values of renal masses, normal renal parenchyma, the ipsilateral psoas muscle and external air on the pre- and post-contrast sequences. The absolute and percentage changes in the mean ROI values were calculated. The readers were blinded to the pathology results. 104 patients were included in this study (mean age of 65 years; 58 males and 46 females). 74 patients (71%) had a diagnosis of renal cell carcinoma (RCC). Pathology showed clear-cell RCC in 55%, papillary RCC in 22%, and other RCC subtypes in 23%. There were 30 non-RCC renal lesions (29%), including oncocytoma, renal papillary adenoma, and renal metastasis.The minimum percentage change in ROI values in the pre- versus post-contrast images for all pathology-proven RCCs was 23% (range: 23-437%, m...Continue Reading

References

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Citations

Sep 6, 2020·Magnetic Resonance Imaging·Daisuke YoshimaruKazuhiro Saito
Jul 6, 2020·Seminars in Ultrasound, CT, and MR·Besma MusaddaqConrad von Stempel
May 25, 2020·Seminars in Ultrasound, CT, and MR·Colleen M CostelloeJohn E Madewell

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