Validation of Repeated Endothelial Function Measurements Using EndoPAT in Stroke

Frontiers in Neurology
Aina S HansenChristina Kruuse

Abstract

Decreased endothelial function (EF) may be a prognostic marker for stroke. Measuring pharmacological effects on EF may be of interest in the development of personalized medicine for stroke prevention. In this study, we assessed the reliability of repeated EF measurements using a pulse amplitude tonometry technology in acute stroke patients. Similarly, reliability was tested in healthy subjects devoid of vascular disease to estimate reactivity and reliability in a younger non-stroke population. EF was assessed using the EndoPAT2000 in 20 healthy volunteers (men 50%, mean age 35.85 ± 3.47 years) and 21 stroke patients (men 52%, mean age 66.38 ± 2.85 years, and mean NIHSS 4.09 ± 0.53) under standardized conditions. EF was measured as the reactive hyperemia index (RHI), logarithm of RHI (lnRHI), and Framingham RHI (fRHI). Measurements were separated by 1.5 and 24 h to assess same-day and day-to-day reliability, respectively. Fair to moderate correlations of measurements [intraclass correlation coefficient (ICC)same-day 0.29 and ICCday-to-day 0.52] were detected in healthy subjects. In stroke patients, we found moderate to substantial correlation of both same-day and day-to-day repeated measurements (ICCsame-day 0.40 and ICCday-to-d...Continue Reading

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Citations

Jan 3, 2019·Journal of Pediatric Gastroenterology and Nutrition·Rebecca WindermanSteven M Schwarz
Oct 10, 2020·Brain Communications·Joakim ÖlmestigChristina Kruuse
May 4, 2021·Translational Journal of the American College of Sports Medicine·Andrea T DuranKeith M Diaz
Jul 7, 2021·Journal of the American Heart Association·Nicolas Martinez-MajanderJukka Putaala

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Software Mentioned

dplyr
Rstudio
Stats
EndoPAT
BlandAltmanLeh
ICC

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