Validation of Smart Nanoparticles as Controlled Drug Delivery Systems: Loading and pH-Dependent Release of Pilocarpine

ACS Omega
Elsa GalbisJuan A Galbis

Abstract

Micelles are good devices for use as controlled drug delivery systems because they exhibit the ability to protect the encapsulated substance from the routes of degradation until they reach the site of action. The present work assesses loading kinetics of a hydrophobic drug, pilocarpine, in polymeric micellar nanoparticles (NPs) and its pH-dependent release in hydrophilic environments. The trigger pH stimulus, pH 5.5, was the value encountered in damaged tissues in solid tumors. The new nanoparticles were prepared from an amphiphilic block copolymer, [(HEMA19%-DMA31%)-(FMA5%-DEA45%)]. For the present research, three systems were validated, two of them with cross-linked cores and the other without chemical stabilization. A comparison of their loading kinetics and release profiles is discussed, with the support of additional data obtained by scanning electron microscopy and dynamic light scattering. The drug was loaded into the NPs within the first minutes; the load was dependent on the degree of cross-linking. All of the systems experienced a boost in drug release at acidic pH, ranging from 50 to 80% within the first 48 h. NPs with the highest degree (20%) of core cross-linking delivered the highest percentage of drug at fixed ti...Continue Reading

References

Jun 29, 2007·International Journal of Pharmaceutics·Stefano SalmasoPaolo Caliceti
Dec 14, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jesse B WolinskyMark W Grinstaff
Dec 25, 2012·Nanomedicine : Nanotechnology, Biology, and Medicine·Bivash MandalGeorge C Wood
May 9, 2014·Chemical Communications : Chem Comm·Carmen Alvarez-Lorenzo, Angel Concheiro
Jan 10, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Swati BiswasBalaram Ghosh
Jan 19, 2016·Chemical Society Reviews·Mahdi KarimiMichael R Hamblin
Jan 30, 2016·Oral Diseases·Daniel BelstrømAnne Marie Lynge Pedersen

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Citations

Oct 31, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jing QuQing-Han Zhou
Jan 24, 2019·International Journal of Molecular Sciences·Nieves IglesiasM-Violante de-Paz

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Methods Mentioned

BETA
scanning
dynamic light scattering
nuclear magnetic resonance
fluorescence microscopy

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