Validation of survival prognostic models for non-small-cell lung cancer in stage- and age-specific groups

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Xiaofei WangHerbert Pang

Abstract

Prognostic models have been proposed to predict survival for non-small-cell lung cancer (NSCLC). It is important to evaluate whether these models perform better than performance status (PS) alone in stage- and age-specific subgroups. The validation cohort included 2060 stage I and 1611 stage IV NSCLC patients from 23CALGB studies. For stage I, Blanchon (B), Chansky (C) and Gail (G) models were evaluated along with the PS only model. For stage IV, Blanchon (B) and Mandrekar (M) models were compared with the PS only model. The c-index was used to assess the concordance between survival and risk scores. The c-index difference (c-difference) and the integrated discrimination improvement (IDI) were used to determine the improvement of these models over the PS only model. For stage I, B and PS have better survival separation. The c-index for B, PS, C and G are 0.61, 0.58, 0.57 and 0.52, respectively, and B performs significantly better than PS with c-difference=0.034. For stage IV, B, M and PS have c-index 0.61, 0.64 and 0.60, respectively; B and M perform significantly better than PS with c-difference=0.015 and 0.033, respectively. Although some prognostic models have better concordance with survival than the PS only model, the abso...Continue Reading

References

Dec 1, 1982·American Journal of Clinical Oncology·M M OkenP P Carbone
Dec 1, 1995·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·J J MuscatoM R Green
Jun 1, 1996·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·S L GrazianoM R Green
Mar 8, 2000·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·M C PerryM R Green
Mar 5, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C M Rocha LimaUNKNOWN Cancer Leukemia Group B
Jul 4, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Gregory M LoewenUNKNOWN Cancer and Leukemia Group B
Nov 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Scott J SwansonDavid J Sugarbaker
Feb 19, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Martin J EdelmanMark J Green
Oct 2, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Antonius A MillerUNKNOWN Cancer and Leukemia Group B (CALGB)
Jan 31, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Michael J LiptayUNKNOWN Thoracic Surgery Subcommittee of the Cancer and Leukemia Group B
May 22, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Kari ChanskyUNKNOWN International Staging Committee and Participating Institutions
Aug 26, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rogerio LilenbaumEverett Vokes
Nov 26, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey A BogartMark R Green
Jan 5, 2011·Statistics in Medicine·Michael J PencinaEwout W Steyerberg
Aug 4, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Arti HurriaWilliam P Tew
May 2, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pasi A JänneVincent A Miller
Jul 31, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Tien HoangDavid H Johnson
Sep 19, 2012·Seminars in Radiation Oncology·Ronald C ChenBryce B Reeve
Jan 15, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Rebecca S HeistUNKNOWN Alliance for Clinical Trials in Oncology
Dec 17, 2014·The Annals of Thoracic Surgery·Chukwumere E NwoguUNKNOWN Alliance for Clinical Trials in Oncology

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Citations

Feb 7, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Marliese AlexanderDavid Ball
Oct 4, 2017·BMC Medical Informatics and Decision Making·D RévészV M H Coupé
Jul 24, 2018·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Tahreem AhmedHoriana B Grosu

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