Validation of targets and drug candidates in an engineered three-dimensional cardiac tissue model

Drug Discovery Today
Barbara T NavéThomas Henkel

Abstract

High-throughput target discovery confronts the biopharmaceutical industry with a plethora of target candidates. The validation of these candidates in disease-specific animal models often lacks the required throughput. Here, we discuss perspectives and limitations of a novel engineered three-dimensional cardiac tissue, which enables the influence of gene and drug intervention to be monitored on a cellular and molecular level under physiological conditions in sufficient throughput. The model is an extremely helpful filter to prioritize multiple development candidates before moving a project into large animal models with higher predictivity.

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Citations

May 5, 2004·Best Practice & Research. Clinical Rheumatology·Jochen G Salfeld
May 19, 2004·Biomaterials·Emilia EntchevaYordan Kostov
Jul 20, 2007·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Jessica L FranchiniMichael J Yost
Jan 31, 2003·Expert Opinion on Therapeutic Targets·Volker RoenickeThomas Henkel
Apr 24, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Lihong YinEmilia Entcheva

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