Validation of the 16-Gene Recurrence Score in Patients with Locoregional, High-Risk Renal Cell Carcinoma from a Phase III Trial of Adjuvant Sunitinib.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Brian I RiniAlain Ravaud

Abstract

Purpose: Adjuvant sunitinib prolonged disease-free survival (DFS; HR, 0.76) in patients with locoregional high-risk renal cell carcinoma (RCC) in the S-TRAC trial (ClinicalTrials.gov NCT00375674). The 16-gene Recurrence Score (RS) assay was previously developed and validated to estimate risk for disease recurrence in patients with RCC after nephrectomy. This analysis further validated the prognostic value of RS assay in patients from S-TRAC and explored the association of RS results with prediction of sunitinib benefit.Patients and Methods: The analysis was prospectively designed with prespecified genes, algorithm, endpoints, and analytical methods. Primary RCC was available from 212 patients with informed consent; primary analysis focused on patients with T3 RCC. Gene expression was quantitated by RT-PCR. Time to recurrence (TTR), DFS, and renal cancer-specific survival (RCSS) were analyzed using Cox proportional hazards regression.Results: Baseline characteristics were similar between patients with and those without RS results, and between the sunitinib and placebo arms among patients with RS results. RS results predicted TTR, DFS, and RCSS in both arms, with the strongest results observed in the placebo arm. When high versus...Continue Reading

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Citations

Jan 24, 2019·Expert Review of Anticancer Therapy·Jarred P ReedRobert A Figlin
Nov 21, 2018·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Janice P Dutcher
May 6, 2019·Current Treatment Options in Oncology·Nieves Martinez ChanzaLauren C Harshman
Mar 4, 2020·Oncogene·Melissa M WolfKathryn E Beckermann
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Jun 21, 2020·Nature Reviews. Nephrology·Nazli DizmanSumanta K Pal
Nov 8, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Daniel J GeorgeAlain Ravaud
Sep 1, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wenxin XuRupal S Bhatt
Mar 11, 2021·Analytical Cellular Pathology (Amsterdam)·Ping WuGuangzhen Wu
Feb 9, 2020·Urology·Naveen S VasudevRosamonde E Banks
Jun 18, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anup PatelDaniel J George
Apr 28, 2021·Cancer Treatment Reviews·Mathieu LarroquetteMarine Gross-Goupil
Jul 6, 2020·Bulletin du cancer·Audrey SimonaggioYann-Alexandre Vano

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