PMID: 7574054Oct 1, 1995Paper

Validation of the alfentanil canonical univariate parameter as a measure of opioid effect on the electroencephalogram

Anesthesiology
P L GambúsS L Shafer

Abstract

Several parameters derived from the multivariate electroencephalographic (EEG) signal have been used to characterize the effects of opioids on the central nervous system. These parameters were formulated on an empirical basis. A new statistical method, semilinear canonical correlation, has been used to construct a new EEG parameter (a certain combination of the powers in the EEG power spectrum) that correlates maximally with the concentration of alfentanil at the effect site. To date, this new canonical univariate parameter (CUP) has been tested only in a small sample of subjects receiving alfentanil. The CUP was tested on EEG data from prior studies of the effect of five opioids: alfentanil (n = 5), fentanyl (n = 15), sufentanil (n = 11), trefentanil (n = 5), and remifentanil (n = 8). We compared the CUP to the commonly used EEG parameter spectral edge, SE95%. The comparison was based on the signal to noise ratio, obtained by fitting a nonlinear pharmacodynamic model to both parameters. The pharmacodynamic parameter estimates obtained using both measurements were also compared. The values for signal-to-noise ratio were significantly greater for the CUP than for SE95% when considering all the opioids at once. The pharmacodynami...Continue Reading

References

Mar 1, 1979·Clinical Pharmacology and Therapeutics·L B SheinerJ Ham
Dec 1, 1992·Journal of Pharmacokinetics and Biopharmaceutics·K M GreggS L Shafer
Jan 1, 1991·Anesthesiology·S L Shafer, J R Varvel
Jul 1, 1986·Clinical Pharmacology and Therapeutics·J D UnadkatL B Sheiner

❮ Previous
Next ❯

Citations

Dec 31, 2004·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Martin LuginbühlThomas W Schnider
May 24, 2005·Journal of Pain and Symptom Management·Jörn Lötsch
May 14, 1998·Neuroscience and Biobehavioral Reviews·N SalanskyA Bondar
Oct 20, 2006·Clinical Pharmacokinetics·Jörn LötschGerd Geisslinger
Jun 9, 1999·Anesthesiology·T W SchniderE J Youngs
Jan 23, 2016·Anesthesia and Analgesia·Maxime Cannesson, Steven L Shafer
Jan 10, 2002·Anesthesiology Clinics of North America·C Rosow, P J Manberg
Jun 1, 2006·Clinical EEG and Neuroscience·M J BarbanojF Jané
Jan 5, 2002·Annales Françaises D'anesthèsie Et De Rèanimation·V Billard, I Constant
Jan 18, 2006·British Journal of Anaesthesia·M LuginbühlS Petersen-Felix

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.