Validation of the Concept of a Common Typical Time of Disease Duration for Hepatocellular Carcinoma Patients Using the Fisher Information Processing of Tumor Imaging Results Combined With Network Phenotyping Strategy Quantification of Individual Patient Clinical Profile Patterns

Seminars in Oncology
Petr PancoskaBrian I Carr

Abstract

A primary goal of current clinical cancer research is the identification of prognostic tumor subtypes. It is increasingly clear that tumor growth depends on both internal tumor factors, and factors that are external to the tumor, such as microenvironment. We recently showed that parameter values alone are less important than the patterns of all patient parameters together for the identification of prognostic subtypes and have identified a network phenotyping strategy method to quantitatively describe the dependency of the tumor on the environment, to characterize hepatocellular carcinoma (HCC) subtypes. We have also shown that information about tumor mass together with patterns of other prognostic factors is related to survival. We now use a different patient cohort to validate this prognostic approach. A main finding is our identification of a common time of total disease duration (TDD) for every HCC patient. Clinical prognosis at the time of baseline patient evaluation is then calculable as the difference between TDD and the time from disease onset to diagnosis (T(onset)). We show that the total pattern of all parameter values and the differences in the relationships between this pattern and a reference pattern that, together...Continue Reading

References

Oct 17, 2008·The New England Journal of Medicine·Yujin HoshidaTodd R Golub
Jul 24, 2012·International Journal of Clinical Oncology·Kei HorinoHideo Baba
Sep 26, 2012·Oncology·Brian I CarrPetr Pancoska
Jan 15, 2013·Gastroenterology·Virginia Hernandez-GeaJosep M Llovet
Aug 21, 2013·Journal of Gastrointestinal & Digestive System·Petr PancoskaBrian I Carr
May 3, 2014·Seminars in Oncology·Petr Pancoska, Brian I Carr
Jul 16, 2014·Seminars in Oncology·Brian I CarrUNKNOWN Italian Liver Cancer (ITA.LI.CA) group

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