Validation of the diagnostic value of NMP22 BladderChek test as a marker for bladder cancer by photodynamic diagnosis

European Urology
Stefan TritschlerDirk Zaak


The aim of the present study was to validate the sensitivity and specificity of the new "point-of-care" NMP22 BladderChek test compared to photodynamic diagnosis (PDD). Voided urine samples from 100 patients with suspicion of bladder cancer were collected to perform the NMP22 BladderChek test and voided urinary cytology. The nuclear matrix protein 22 (NMP22) levels were measured by a lateral flow immunochromatographic qualitative assay, using 10 U/ml as the cut-off value. Subsequently patients underwent PDD, using 5-aminolevulinic acid or hexyl-aminolevulinate; previous bladder washings for cytology were collected. Sensitivity and specificity of the NMP22 BladderChek test were compared with cytology and PDD. Forty of the 100 patients had urothelial malignancies (22 pTa, 4 pT1, 3 pT2, 9 carcinoma in situ, 2 pTx; 16 G1, 6 G2, 18 G3). The sensitivity was 65% for the NMP22 BladderChek test, 44% for voided cytology, 75% for washing cytology, and 93% for PDD. Specificity rates were 40%, 78%, 62%, and 43%, respectively. Positive predictive values were 0.42, 0.58, 0.53, and 0.52 and the negative predictive values 0.63, 0.68, 0.82, and 0.9, respectively. The results demonstrate that the NMP22 BladderChek is an easily applied test, givin...Continue Reading


Jun 29, 1999·Cancer·S BastackyW M Murphy
May 29, 2003·The Journal of Urology·Afina S GlasKarl H Kurth
Dec 11, 2003·The Journal of Urology·Jörg SchmidbauerHexvix PCB301/01 Study Group
Nov 5, 2004·Expert Review of Molecular Diagnostics·Kevin M Tomera
Feb 17, 2005·JAMA : the Journal of the American Medical Association·H Barton GrossmanYu Shen
Jun 1, 2005·European Urology·Bas W G van RhijnTheo H van der Kwast
Jul 9, 2005·BJU International·Dirk ZaakChristian Stief
Nov 1, 2005·European Urology·Paula M J MoonenJ Alfred Witjes


Oct 26, 2006·Der Urologe. Ausg. A·Stefan TritschlerChristian Stief
Oct 12, 2007·Der Urologe. Ausg. A·Dirk ZaakChristian Stief
Jun 21, 2013·Der Urologe. Ausg. A·Stefan TritschlerChristian Stief
Dec 7, 2007·World Journal of Urology·Carvell T Nguyen, J Stephen Jones
Feb 7, 2008·World Journal of Urology·Peter J GoebellBernd J Schmitz-Dräger
Aug 16, 2012·Journal of Cancer Research and Clinical Oncology·Tilman TodenhöferChristian Schwentner
May 8, 2010·Expert Opinion on Biological Therapy·Susanna Lintula, Kristina Hotakainen
Nov 18, 2011·The Journal of Urology·Tilman TodenhöferChristian Schwentner
Apr 13, 2011·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·F SaintSous-comité vessie du Comité de cancérologie de l'AFU
Dec 22, 2007·European Urology·Dieter JochamRaphaela Waidelich
Dec 29, 2007·European Urology·Olaf P J Vrooman, J Alfred Witjes
Jul 18, 2008·Cytopathology : Official Journal of the British Society for Clinical Cytology·K KapilaF Al-Mulla
Nov 28, 2008·BJU International·Badrinath Konety, Yair Lotan
Mar 21, 2009·International Journal of Urology : Official Journal of the Japanese Urological Association·Olaf P J Vrooman, J Alfred Witjes
Dec 14, 2011·Advances in Urology·Joerg HennenlotterArnulf Stenzl
Oct 19, 2017·Diagnostics·Chiuan Herng LeowJames McCarthy
Jan 15, 2014·Urologia·Fabrizio Dal MoroFiliberto Zattoni
Sep 1, 2007·Current Opinion in Urology·Alonso Alvarez, Vinata B Lokeshwar
Jun 19, 2013·Expert Review of Anticancer Therapy·Ernesto R CordeiroTheo M de Reijke

Related Concepts

Malignant Neoplasm of Urinary Bladder
Diagnostic Techniques, Urological
Nucleolar Proteins

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.