Validation of the isovolumetric relaxation time for the estimation of pulmonary systolic arterial blood pressure in chronic pulmonary hypertension

European Heart Journal Cardiovascular Imaging
Inês Zimbarra CabritaPetros Nihoyannopoulos

Abstract

Transthoracic echocardiography is a useful technique for non-invasive detection of pulmonary arterial systolic pressure (PASP). Isovolumic relaxation time (IVRT) measured by Doppler tissue imaging (DTI) is a sensitive measurement of changes in pulmonary vasculature. Our aim was to validate IVRT in the echocardiographic assessment of pulmonary hypertension (PH) patients. We studied 196 PH patients (67% women, mean age 51.8 ± 16.6 years, mean PASP: 81 ± 24 mmHg) and 37 consecutive age- and sex-matched controls (58% women, mean age 44.7 ± 16.4 years, mean PASP 27.7 ± 5.5 mmHg). The estimation of PASP was derived from tricuspid regurgitation velocity according to the Bernoulli equation. The measurement of IVRT was calculated using pulsed tissue Doppler. In the PH group and in the healthy volunteers group (P < 0.0001), the average IVRT was 113.4 ± 28.5 ms [95% confidence interval (CI): 109-117] and 41 ± 12.5 ms (95% CI: 37-45), respectively. We found a strong correlation between IVRT and systolic pulmonary pressure in the PH group (r = 0.52, P < 0.0001) and a cut-off of 75 ms showed a sensitivity and specificity of 94% and 97%, respectively, for the prediction of elevated PASP. The determination of IVRT by DTI is a simple and reprod...Continue Reading

References

Feb 1, 1988·Journal of the American College of Cardiology·D TriffonR V Ditchey
Nov 1, 1996·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·D D BorgesonA J Tajik
Aug 23, 2000·European Heart Journal·L Hatle, G R Sutherland
Oct 11, 2001·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·P CasoN Mininni
Mar 30, 2002·Journal of the American College of Cardiology·Ronald J RaymondWalker Long
Jul 13, 2002·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·G K EfthimiadisG E Louridas
May 4, 2004·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Darryl MillerBrian D Hoit
Oct 27, 2004·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Amr AbbasChristopher Appleton
May 13, 2005·Chest·Eduardo BossoneLuigi Allegra
Jul 5, 2005·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·J De BackerJ De Sutter
Nov 9, 2005·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Virginija DambrauskaiteGeorge R Sutherland
Jan 10, 2006·Clinical Physiology and Functional Imaging·Per LindqvistElsadig Kazzam
May 5, 2006·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Anthony S McLeanSarah Wesley
Feb 23, 2007·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Antonio VitarelliSalvatore Rosanio
May 9, 2007·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Mohamed Fahmy Elnoamany, Ashraf Abdelraouf Dawood
May 15, 2007·Journal of the American College of Cardiology·Cheuk-Man YuJae K Oh
Jun 5, 2007·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Kwan S LeeSteven J Lester
May 21, 2008·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Nicolas BréchotRaymond Roudaut
Jul 9, 2009·Journal of the American College of Cardiology·Gérald SimonneauRogério Souza
Apr 23, 2010·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Inês Zimbarra CabritaJ Simon R Gibbs
Dec 2, 2011·European Respiratory Review : an Official Journal of the European Respiratory Society·L S Howard

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Citations

Oct 16, 2010·Internal and Emergency Medicine·Michele CorrealeMatteo Di Biase
May 28, 2015·Cardiovascular Research·André La Gerche, Piet Claus
Jan 31, 2015·Heart Failure Reviews·Richard G AxellPaul A White
Apr 7, 2016·Archives of Disease in Childhood. Fetal and Neonatal Edition·Phani Kiran YajamanyamAndrew K Ewer
Aug 19, 2015·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Xiao-Zhi ZhengBin Yang
Oct 3, 2013·Seminars in Cardiothoracic and Vascular Anesthesia·Alina NicoaraMadhav Swaminathan
Aug 20, 2019·European Journal of Preventive Cardiology·Blanca Domenech-XimenosMarta Sitges
Jan 26, 2017·The International Journal of Cardiovascular Imaging·Myriam AmsallemFrançois Haddad
Jul 29, 2016·Current Opinion in Cardiology·Myriam AmsallemFrançois Haddad
Jul 30, 2020·International Journal of Environmental Research and Public Health·Zuzanna Lewicka-PotockaGrzegorz Raczak

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