Validation of the Kidney Donor Profile Index (KDPI) to assess a deceased donor's kidneys' outcome in a European cohort

Scientific Reports
Maximilian DahmenStefan Reuter

Abstract

The Kidney Donor Profile Index (KDPI) was introduced in the United States in 2014 to guide the decision making of clinicians with respect to accepting or declining a donated kidney. To evaluate whether the KDPI can be applied to a European cohort, we retrospectively assessed 580 adult patients who underwent renal transplantation (brain-dead donors) between January 2007 and December 2014 at our center and compared their KDPIs with their short- and long-term outcomes. This led to the observation of two associations: one between the KDPI and the estimated glomerular filtration rate at one year (1-y-eGFR) and the other between the KDPI and the death-censored allograft survival rate (both p < 0.001). Following this, the individual input factors of the KDPI were analyzed to assess their potential to evaluate the quality of a donor organ. We found that a donor's age alone is significantly predictive in terms of 1-y-eGFR and death-censored allograft survival (both p < 0.001). Therefore, a donor's age may serve as a simple reference for future graft function. Furthermore, we found that an organ with a low KDPI or from a young donor has an improved graft survival rate whereas kidneys with a high KDPI or from an older donor yield an infer...Continue Reading

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Citations

Oct 7, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Robert PearsonMarc J Clancy
Feb 3, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Christian KuhnDaniel Sidler
Jan 22, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Piyavadee HomkrailasSuphamai Bunnapradist
May 7, 2021·Nature Reviews. Nephrology·Raymond VanholderGabriel C Oniscu

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BETA
biopsies

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SPSS® Statistics

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