Validation of the Martin Method for Estimating Low-Density Lipoprotein Cholesterol Levels in Korean Adults: Findings from the Korea National Health and Nutrition Examination Survey, 2009-2011

PloS One
Jongseok LeeHeejeong Son

Abstract

Despite the importance of accurate assessment for low-density lipoprotein cholesterol (LDL-C), the Friedewald formula has primarily been used as a cost-effective method to estimate LDL-C when triglycerides are less than 400 mg/dL. In a recent study, an alternative to the formula was proposed to improve estimation of LDL-C. We evaluated the performance of the novel method versus the Friedewald formula using a sample of 5,642 Korean adults with LDL-C measured by an enzymatic homogeneous assay (LDL-CD). Friedewald LDL-C (LDL-CF) was estimated using a fixed factor of 5 for the ratio of triglycerides to very-low-density lipoprotein cholesterol (TG:VLDL-C ratio). However, the novel LDL-C (LDL-CN) estimates were calculated using the N-strata-specific median TG:VLDL-C ratios, LDL-C5 and LDL-C25 from respective ratios derived from our data set, and LDL-C180 from the 180-cell table reported by the original study. Compared with LDL-CF, each LDL-CN estimate exhibited a significantly higher overall concordance in the NCEP-ATP III guideline classification with LDL-CD (p< 0.001 for each comparison). Overall concordance was 78.2% for LDL-CF, 81.6% for LDL-C5, 82.3% for LDL-C25, and 82.0% for LDL-C180. Compared to LDL-C5, LDL-C25 significantly ...Continue Reading

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Citations

Mar 9, 2018·Scandinavian Journal of Clinical and Laboratory Investigation·Caio Mauricio Mendes de CordovaTill Ittermann
Dec 5, 2017·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Soie Chung
May 29, 2019·Current Opinion in Lipidology·Soie Chung
Jun 3, 2017·American Journal of Clinical Pathology·Stephen M RoperSridevi Devaraj
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May 9, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Arrigo F G CiceroUNKNOWN BLIP Study group
Jul 23, 2021·European Heart Journal·Renato QuispeMohamed Badreldin Elshazly
Aug 15, 2021·Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology·Cátia FerrinhoSequeira Duarte
Oct 13, 2021·Laboratory Medicine·Hikmet Can Çubukçu, Deniz İlhan Topcu

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