Validation of the MDS clinical diagnostic criteria for Parkinson's disease

Movement Disorders : Official Journal of the Movement Disorder Society
Ronald B PostumaDaniela Berg

Abstract

In 2015, the International Parkinson and Movement Disorder Society published clinical diagnostic criteria for Parkinson's disease. These criteria aimed to codify/reproduce the expert clinical diagnostic process and to help standardize diagnosis in research and clinical settings. Their accuracy compared with expert clinical diagnosis has not been tested. The objectives of this study were to validate the International Parkinson and Movement Disorder Society diagnostic criteria against a gold standard of expert clinical diagnosis, and to compare concordance/accuracy of the International Parkinson and Movement Disorder Society criteria to 1988 United Kingdom Brain Bank criteria. From 8 centers, we recruited 626 parkinsonism patients (434 PD, 192 non-PD). An expert neurologist diagnosed each patient as having PD or non-PD, regardless of International Parkinson and Movement Disorder Society criteria (gold standard, clinical diagnosis). Then a second neurologist evaluated the presence/absence of each individual item from the International Parkinson and Movement Disorder Society criteria. The overall accuracy/concordance rate, sensitivity, and specificity of the International Parkinson and Movement Disorder Society criteria compared wi...Continue Reading

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Citations

Feb 7, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Martje E van EgmondMarina A Tijssen
Feb 7, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Farwa AliKeith A Josephs
Mar 15, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Yu GuoJin-Tai Yu
Apr 6, 2019·Journal of Neural Transmission·Rezzak YilmazDaniela Berg
Feb 14, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Aldo QuattroneMaria Salsone
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