Validation of the Memorial Sloan Kettering Cancer Center nomogram for predicting non-sentinel lymph node metastasis in sentinel lymph node-positive breast-cancer patients

OncoTargets and Therapy
Xiang BiPeng-fei Qiu

Abstract

The main purpose of the study reported here was to validate the clinical value of the Memorial Sloan Kettering Cancer Center (MSKCC) nomogram that predicts non-sentinel lymph node (SLN) metastasis in SLN-positive patients with breast cancer. Data on 1,576 patients who received sentinel lymph node biopsy (SLNB) at the Shandong Cancer Hospital from December 2001 to March 2014 were collected in this study, and data on 509 patients with positive SLN were analyzed to evaluate the risk factors for non-SLN metastasis. The MSKCC nomogram was used to estimate the probability of non-SLN metastasis and was compared with actual probability after grouping into deciles. A receiver-operating characteristic (ROC) curve was drawn and predictive accuracy was assessed by calculating the area under the ROC curve. Tumor size, histological grade, lymphovascular invasion, multifocality, number of positive SLNs, and number of negative SLNs were correlated with non-SLN metastasis (P<0.05) by univariate analysis. However, multivariate analysis showed that tumor size (P=0.039), histological grade (P=0.043), lymphovascular invasion (P=0.001), number of positive SLNs (P=0.001), and number of negative SLNs (P=0.000) were identified as independent predictors...Continue Reading

Citations

Jun 22, 2016·The Breast : Official Journal of the European Society of Mastology·Lídia Alves-RibeiroJosé Luís Fougo
Jan 19, 2017·Oncotarget·Chun Guang GuoJian Qiang Cai
Mar 5, 2016·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yaohui WangZhiheng Chen
Apr 20, 2018·Frontiers in Oncology·Maïlys de Meric de BellefonCeline Bourgier

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Methods Mentioned

BETA
biopsy
dissection
X-ray

Software Mentioned

SPSS

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