Validation of the Oswestry Risk of Knee Arthroplasty Index (ORKA-1) for Patients Undergoing Autologous Chondrocyte Implantation.

Cartilage
Jakob AckermannAndreas H Gomoll

Abstract

The purpose of this study was first to externally validate the Oswestry Risk of Knee Arthroplasty index (ORKA-1) by applying it to an autologous chondrocyte implantation (ACI) patient cohort in the United States with a broader definition of failure than only arthroplasty, and second, to determine predictive factors for the risk of ACI failure as defined by the senior author. A total of 171 patients that underwent ACI were included to validate the ORKA-1 as all factors needed for calculation and outcomes were recorded. For Cox regression analysis, 154 patients were included as they completed preoperative Knee Injury and Osteoarthritis Outcome Score (KOOS), Tegner, Lysholm, International Knee Documentation Committee (IKDC), and 12-item Shor Form (SF-12) scores. Patient- and lesion-associated parameters were recorded for each patient. At final follow-up (maximum of 10 years post-ACI), a total of 27 patients (15.8%) were considered a failure by senior author's definition. With ACI failure as endpoint, the mean survival was 7.96 years in risk group 1 and 5.4 years in risk group 5. Cox regression analysis identified preoperative KOOS Sport/Recreation as the only significant predictive factor for ACI failure (P = 0.007). The ORKA-1 is...Continue Reading

References

Oct 6, 1994·The New England Journal of Medicine·M BrittbergL Peterson
Mar 5, 2004·The Journal of Bone and Joint Surgery. American Volume·Gunnar KnutsenOddmund Johansen
Dec 21, 2005·The Journal of Bone and Joint Surgery. British Volume·S P KrishnanG Bentley
Oct 3, 2007·The Journal of Bone and Joint Surgery. American Volume·Gunnar KnutsenOddmund Johansen
Mar 17, 2009·The American Journal of Sports Medicine·Allison G McNickleBrian J Cole
Oct 29, 2009·The American Journal of Sports Medicine·Abhijit M BhosaleJames B Richardson
Jan 12, 2010·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Erhan BasadJürgen Steinmeyer
Jan 22, 2010·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Marta Gonzalez Sáenz de TejadaCristina Sarasqueta
Feb 26, 2010·The American Journal of Sports Medicine·Lars PetersonAnders Lindahl
May 8, 2010·The American Journal of Sports Medicine·J Bruce MoseleyChristoph Erggelet
May 26, 2012·Current Reviews in Musculoskeletal Medicine·Marco Demange, Andreas H Gomoll
Aug 28, 2013·Clinical Orthopaedics and Related Research·Tom MinasAndreas H Gomoll
Jan 4, 2017·Sports Medicine and Arthroscopy Review·Luca AndrioloElizaveta Kon
Mar 1, 2017·Health Technology Assessment : HTA·Hema MistryNorman Waugh
Mar 28, 2017·Cartilage·M Naomi DugardJames B Richardson
Jul 27, 2017·The American Journal of Sports Medicine·Takahiro OguraTom Minas

❮ Previous
Next ❯

Software Mentioned

Stata
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.