Validation of the Pancreas Donor Risk Index for use in a UK population

Transplant International : Official Journal of the European Society for Organ Transplantation
Shruti MittalAnil Vaidya

Abstract

Pancreas graft failure rates remain substantial. The PDRI can be used at the time of organ offering, to predict one-year graft survival. This study aimed to validate the PDRI for a UK population. Data for 1021 pancreas transplants were retrieved from a national database for all pancreas transplants. Cases were categorized by PDRI quartile and compared for death-censored graft survival. Significant differences were observed between the UK and US cohorts. The PDRI accurately discriminated graft survival for SPK and was associated with a hazard ratio of 1.52 (P = 0.009) in this group. However, in the PTA and PAK groups, no association between PDRI quartile and graft survival was observed. This is the largest study to validate the PDRI in a European cohort and has shown for the first time that the PDRI can be used as a tool to predict graft survival in SPK transplantation, but not PTA or PAK transplantation.

References

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Dec 10, 2013·Diabetic Medicine : a Journal of the British Diabetic Association·S Mittal, S C L Gough

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Citations

Apr 29, 2015·Transplant International : Official Journal of the European Society for Organ Transplantation·Thierry Berney, Raja Kandaswamy
May 18, 2016·Transplant International : Official Journal of the European Society for Organ Transplantation·Wouter H KoppAndries E Braat
Jul 6, 2017·Current Opinion in Organ Transplantation·Shruti MittalPeter J Friend
May 26, 2017·Current Opinion in Organ Transplantation·Erik Stites, Alexander C Wiseman
Oct 18, 2016·Current Opinion in Nephrology and Hypertension·Erik StitesAlexander C Wiseman
Apr 9, 2016·Current Opinion in Organ Transplantation·Jerome M Laurence, Mark S Cattral
Feb 18, 2020·Clinical Transplantation·Ankur Pranjal ChoubeyJorge Ortiz
Jan 1, 2019·World Journal of Transplantation·Emmanouil GiorgakisAndrew L Singer
Nov 1, 2017·British Medical Bulletin·S DholakiaP J Friend
Feb 26, 2021·The Journal of International Medical Research·Shengmin MeiZhenhua Hu
Nov 24, 2021·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Ky-Leigh AngUsman Khalid

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