Validation of the prognostic value of new sub-stages within the AJCC 8th edition of non-small cell lung cancer

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Omar Abdel-Rahman

Abstract

The 8th edition of the American Joint Committee on Cancer (AJCC) staging system for non-small cell lung cancer (NSCLC) has been released. The current study tried to validate the prognostic significance of the new system among patients registered within the surveillance, epidemiology and end results (SEER) database. SEER database (2010-2013) has been accessed through SEER*Stat program and AJCC 8th edition stages were reconstructed utilizing the collaborative stage descriptions. Overall and lung cancer-specific survival analyses according to both 7th and 8th editions were conducted through Kaplan-Meier analysis and multivariate analysis was conducted through a Cox proportional hazard model. A total of 127,096 patients with NSCLC were identified in the period from 2010 to 2013. For overall survival assessment according to the 8th edition, P values for all pair-wise comparisons among different stages were significant (<0.0001) except for the comparisons between stage IB and IIA (P = 0.146); stage IIA and IIB (P = 0.165). For lung cancer-specific survival according to the 8th edition, P values for all pair-wise comparisons among different stages were significant (<0.001). Among patients with stage I disease, multivariate analysis fo...Continue Reading

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Apr 21, 2017·Current Medical Research and Opinion·Omar Abdel-Rahman

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Citations

Aug 16, 2017·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·O Abdel-Rahman
Oct 13, 2017·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·O Abdel-Rahman
Sep 21, 2020·Annals of Surgical Oncology·Durgesh Wankhede
Jan 15, 2020·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Rongjiong ZhengHaiqi Xu
Aug 25, 2019·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Anne JouinotFrançois Goldwasser

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