Validation of the reshaped shared epitope HLA-DRB1 classification in rheumatoid arthritis.

Arthritis Research & Therapy
Laëtitia MichouEuropean Consortium on Rheumatoid Arthritis Families

Abstract

Recently, we proposed a classification of HLA-DRB1 alleles that reshapes the shared epitope hypothesis in rheumatoid arthritis (RA); according to this model, RA is associated with the RAA shared epitope sequence (72-74 positions) and the association is modulated by the amino acids at positions 70 and 71, resulting in six genotypes with different RA risks. This was the first model to take into account the association between the HLA-DRB1 gene and RA, and linkage data for that gene. In the present study we tested this classification for validity in an independent sample. A new sample of the same size and population (100 RA French Caucasian families) was genotyped for the HLA-DRB1 gene. The alleles were grouped as proposed in the new classification: S1 alleles for the sequences A-RAA or E-RAA; S2 for Q or D-K-RAA; S3D for D-R-RAA; S3P for Q or R-R-RAA; and X alleles for no RAA sequence. Transmission of the alleles was investigated. Genotype odds ratio (OR) calculations were performed through conditional logistic regression, and we tested the homogeneity of these ORs with those of the 100 first trio families (one case and both parents) previously reported. As previously observed, the S2 and S3P alleles were significantly over-trans...Continue Reading

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Citations

Feb 6, 2013·Nature Reviews. Rheumatology·Sebastien ViatteSoumya Raychaudhuri
Oct 29, 2008·Annual Review of Pathology·John B Imboden
May 31, 2006·Arthritis Research & Therapy·Robert Winchester
Jul 7, 2007·Arthritis Research & Therapy·Laurent JacqUNKNOWN European Consortium on Rheumatoid Arthritis Families
Mar 1, 2008·Arthritis Research & Therapy·Thomas BarnetchePierre-Antoine Gourraud
Jan 1, 2010·Pharmacogenomics and Personalized Medicine·Darren D O'Rielly, Proton Rahman
Apr 23, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Song LuChris D Platsoucas
Jan 24, 2007·Proceedings of the National Academy of Sciences of the United States of America·Laëtitia MichouUNKNOWN European Consortium on Rheumatoid Arthritis Families
Nov 26, 2015·Journal of Immunology Research·Andreia BettencourtBerta Martins da Silva
Sep 16, 2014·Scandinavian Journal of Rheumatology·M FodilE Petit-Teixeira
Sep 1, 2006·Expert Review of Clinical Immunology·Claire GormanAndrew Cope
Apr 29, 2008·Arthritis and Rheumatism·S Louis BridgesLaura B Hughes
Jul 16, 2010·Expert Review of Molecular Diagnostics·Zsolt B NagyJózsef Gábor Joó
Jan 4, 2012·Tissue Antigens·A BoudjemaS Benhamamouch
Dec 10, 2017·Best Practice & Research. Clinical Rheumatology·Kevin D DeaneV Michael Holers

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