PMID: 11909667Mar 23, 2002Paper

Validation of the STR DXS7424 and the linkage situation on the X-chromosome

Forensic Science International : Synergy
Jeanett EdelmannReinhard Szibor

Abstract

X-linked microsatellite markers have proven to be powerful tools for parentage testing, mainly in deficiency paternity cases when the disputed child is female. However, only a small number of X-linked short tandem repeats (STRs) have been comprehensively described for forensic applications to date. We present sequence and population genetic data of the DXS7424 STR (GDB-G00-577-633) which is a trinucleotide repeat polymorphism representing 12 alleles of 147-180 bp in length. DXS7424 is located at Xq22 and closely linked to DXS101, corresponding to a genetic localisation of 104.9-121 cM from Xp-tel.PCR fragment length measurements and sequencing were carried out using the automatic gene analyser ABI 310 (Applied Biosystems). The population of 764 unrelated Germans checked for this STR exhibited the following features: polymorphism information content (PIC) = 0.780; heterozygosity (Het) = 0.843; mean exclusion chance (MEC = 0.766. Kinship tests revealed a typical X-linked inheritance. In 300 meioses under investigation, mutations were not found. Significant deviations from the Hardy-Weinberg equilibrium (HWE) were not established. Linkage studies confirmed closely linkage to DXS101. Additional we found linkage disequilibrium betwe...Continue Reading

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Citations

Jun 9, 2004·International Journal of Legal Medicine·Hwan Young LeeKyoung-Jin Shin
Sep 1, 2005·International Journal of Legal Medicine·Micaela PoetschReinhard Szibor
Feb 14, 2006·International Journal of Legal Medicine·H AsamuraH Fukushima
Aug 13, 2005·International Journal of Legal Medicine·Reinhard SziborJeanett Edelmann
Nov 18, 2008·International Journal of Legal Medicine·Muhammad Akram TariqSheikh Riazuddin
Dec 18, 2008·International Journal of Legal Medicine·Anna Esteve CodinaWalther Parson
Jan 10, 2009·International Journal of Legal Medicine·Hsiao-Lin HwaTsang-Ming Ko
Feb 21, 2009·International Journal of Legal Medicine·Jeanett EdelmannReinhard Szibor
Nov 26, 2009·International Journal of Legal Medicine·Sandra HeringReinhard Szibor
Apr 30, 2010·International Journal of Legal Medicine·Hsiao-Lin HwaTsang-Ming Ko
Jun 1, 2010·International Journal of Legal Medicine·Yasutaka Nakamura, Kiyoshi Minaguchi
Oct 18, 2011·International Journal of Legal Medicine·Larissa Siqueira PennaLuiz Fernando Jobim
Dec 3, 2003·Forensic Science International : Synergy·Reinhard SziborMatthias Michael
May 28, 2005·Forensic Science International : Synergy·Micaela PoetschEberhard Lignitz
Dec 10, 2013·Forensic Science International. Genetics·Toni M DiegoliMichael D Coble
Sep 10, 2008·Yi chuan = Hereditas·Yan-Jiong ChenTeng Chen
May 9, 2014·International Journal of Legal Medicine·Toni M DiegoliMichael D Coble
May 3, 2014·International Journal of Legal Medicine·Muhammad IsrarPeter Wiegand
Apr 12, 2014·Electrophoresis·Hao-Tian MengXing Wei
Mar 31, 2012·Forensic Science International. Genetics·Michael NothnagelSandra Hering
Oct 15, 2010·Forensic Science International. Genetics·Toni M Diegoli, Michael D Coble
Mar 11, 2010·Forensic Science International. Genetics·Heike RodigWerner Brabetz
May 12, 2010·Forensic Science International. Genetics·Iede H Ferreira da SilvaLuiz Antonio Ferreira da Silva
Dec 17, 2008·Forensic Science International. Genetics·Elzemar Martins Ribeiro RodriguesSidney Emanuel Batista dos Santos
Dec 17, 2008·Forensic Science International. Genetics·Jeanett EdelmannReinhard Szibor
Dec 17, 2008·Forensic Science International. Genetics·Dorit BeckerWerner Brabetz
Jun 1, 2007·Forensic Science International. Genetics·Reinhard Szibor
Dec 2, 2009·Forensic Science International. Genetics·Weiwei WuDejian Lu
Jun 22, 2007·Transfusion·Chiara ToniSilvano Presciuttini
Nov 16, 2004·Forensic Science International : Synergy·Sang Hee ShinKi Wha Chung
Nov 11, 2005·Forensic Science International : Synergy·Shanzhi Gu, Shengbin Li
Nov 11, 2005·Forensic Science International : Synergy·Qingbo Liu, Shengbin Li
Jan 13, 2015·Forensic Science International. Genetics·Krzysztof RębałaZofia Szczerkowska
May 5, 2016·Journal of Zhejiang University. Science. B·Yu-Xin GuoBo-Feng Zhu
Jan 25, 2019·International Journal of Legal Medicine·Cheng XiaoLing Chen
Jul 9, 2008·International Journal of Legal Medicine·Micaela PoetschNicole von Wurmb-Schwark

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