Validation of the World Health Organization/ International Society of Hypertension (WHO/ISH) cardiovascular risk predictions in Sri Lankans based on findings from a prospective cohort study.

PloS One
U B ThulaniA R Wickremasinghe

Abstract

There are no cardiovascular (CV) risk prediction models for Sri Lankans. Different risk prediction models not validated for Sri Lankans are being used to predict CV risk of Sri Lankans. We validated the WHO/ISH (SEAR-B) risk prediction charts prospectively in a population-based cohort of Sri Lankans. We selected 40-64 year-old participants from the Ragama Medical Officer of Health (MOH) area in 2007 by stratified random sampling and followed them up for 10 years. Ten-year risk predictions of a fatal/non-fatal cardiovascular event (CVE) in 2007 were calculated using WHO/ISH (SEAR-B) charts with and without cholesterol. The CVEs that occurred from 2007-2017 were ascertained. Risk predictions in 2007 were validated against observed CVEs in 2017. Of 2517 participants, the mean age was 53.7 year (SD: 6.7) and 1132 (45%) were males. Using WHO/ISH chart with cholesterol, the percentages of subjects with a 10-year CV risk <10%, 10-19%, 20%-29%, 30-39%, ≥40% were 80.7%, 9.9%, 3.8%, 2.5% and 3.1%, respectively. 142 non-fatal and 73 fatal CVEs were observed during follow-up. Among the cohort, 9.4% were predicted of having a CV risk ≥20% and 8.6% CVEs were observed in the risk category. CVEs were within the predictions of WHO/ISH charts wi...Continue Reading

References

Jul 13, 2001·JAMA : the Journal of the American Medical Association·R B D'AgostinoUNKNOWN CHD Risk Prediction Group
May 16, 2003·JAMA : the Journal of the American Medical Association·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Jul 29, 2003·Journal of Epidemiology and Community Health·J MarrugatW B Kannel
Aug 2, 2003·Lancet·Majid EzzatiUNKNOWN Comparative Risk Assessment Collaborating Group
Jun 28, 2006·Circulation·Milan GuptaSubodh Verma
Oct 25, 2006·International Journal of Epidemiology·M WoodwardUNKNOWN Asia Pacific Cohort Studies Collaboration
Jan 20, 2007·Journal of Epidemiology and Community Health·F BarziM Woodward
Jan 24, 2008·Circulation·Ralph B D'AgostinoWilliam B Kannel
Dec 25, 2008·Circulation·Hirotsugu UeshimaTomonori Okamura
May 30, 2009·Journal of Gastroenterology and Hepatology·Anuradha S DassanayakeH Janaka de Silva
Nov 10, 2009·Maturitas·Yen Y TanYvonne T van der Schouw
Mar 16, 2012·Cardiology in Review·Seshasayee NarasimhanKevin R Bainey
Jun 28, 2012·World Journal of Diabetes·Ambady RamachandranArun Nanditha
Oct 29, 2013·International Journal of Vascular Medicine·S Monira HussainAndrew M Tonkin
Feb 12, 2015·Atherosclerosis·Yolande AppelmanSanne A E Peters
May 27, 2015·Nature Reviews. Cardiology·Jenna DeanC Noel Bairey Merz
Sep 13, 2015·International Journal of Public Health·Dipesh P Gopal, Juliet A Usher-Smith
Feb 26, 2016·Diabetes Care·Arun NandithaPaul Z Zimmet
Apr 1, 2016·The Ceylon Medical Journal·U K RanawakaA R Wickramasinghe
Nov 4, 2016·Physiological Reviews·Vera Regitz-Zagrosek, Georgios Kararigas
May 5, 2017·Cardiovascular Research·Renée Ventura-ClapierVera Regitz-Zagrosek
Jul 12, 2019·Journal of the American Heart Association·Fatima RodriguezLatha P Palaniappan

❮ Previous
Next ❯

Software Mentioned

excel
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.