Validation of use of a traditional antimalarial remedy from French Guiana, Zanthoxylum rhoifolium Lam

Journal of Ethnopharmacology
V JullianM Sauvain

Abstract

Zanthoxylum rhoifolium bark (Rutaceae) is a medicinal plant, traditionally used in French Guiana to treat and prevent malaria. Bioassay-guided extractions of Zanthoxylum rhoifolium bark have shown that antiplasmodial activity is concentrated in the alkaloid fraction. Further fractionation of this extract has yielded seven benzophenanthridine alkaloids, dihydroavicine 1, dihydronitidine 2, oxyavicine 3, oxynitidine 4, fagaridine 5, avicine 6 and nitidine 7. Antimalarial activity of the last five compounds has been evaluated, and nitidine was the most potent, displaying an IC(50)<0.27microM against Plasmodium falciparum. Investigation of the traditional remedy, a trunk bark decoction in water, has shown that fagaridine 5, avicine 6 and nitidine 7 are also present in the decoction, therefore justifying the traditional use of Zanthoxylumrhoifolium bark as antimalarial.

References

Dec 1, 1979·Antimicrobial Agents and Chemotherapy·R E DesjardinsJ D Chulay
Feb 1, 1994·Acta Tropica·M C GesslerM Tanner
Dec 1, 1995·Antimicrobial Agents and Chemotherapy·D M GakunjuW M Watkins
Apr 24, 2003·Planta medica·Wellington de A GonzagaAdemir F Morel
Apr 6, 2005·Bioorganic & Medicinal Chemistry Letters·James M NyanguluWilliam M Watkins
Apr 9, 2005·Journal of Ethnopharmacology·M VigneronG Bourdy
Apr 27, 2005·Journal of Ethnopharmacology·S BertaniE Deharo

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Citations

Mar 13, 2012·Malaria Journal·Jérome BouquetAlexis Valentin
Aug 6, 2010·Chemical & Pharmaceutical Bulletin·Hiroyuki FuchinoNobuo Kawahara
Aug 7, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Adrian Martin PohlitFabio Trindade Maranhão Costa
Mar 23, 2010·Journal of Ethnopharmacology·S S PereiraF R C Almeida
Dec 20, 2015·Malaria Journal·Renata B S LimaAdrian M Pohlit
Jul 5, 2011·Journal of Ethnopharmacology·F F B P FreitasF A Oliveira
Aug 8, 2012·Journal of Ethnopharmacology·Gislaine F Moura-CostaTania Ueda-Nakamura
Sep 22, 2016·Malaria Journal·Christopher Dean GoodmanHelle Wangensteen
Nov 7, 2009·Anais Da Academia Brasileira De Ciências·Alaíde B OliveiraMarinete M Póvoa
Apr 30, 2014·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Liping LiHuidi Jiang
Apr 21, 2020·Current Pharmaceutical Biotechnology·Katike UmamaheshObulam Vijaya Sarathi Reddy

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