Validation of western Helicobacter pylori IgG antibody assays in Korean adults

Journal of Medical Microbiology
Sun-Young LeeYeo-Min Yun

Abstract

Helicobacter pylori infection is endemic in Korea, and serology testing is widely performed. The aim of this study was to validate and compare the diagnostic accuracy of Korean and Western serological assays for H. pylori detection in Korean adults. The 114 Korean adults who visited our centre over a 6-month period for the evaluation of H. pylori infection using the urea breath test (UBT) were enrolled in this prospective study. Anti-H. pylori IgG was measured using three commercially available immunoassays: Genedia H. pylori ELISA (Green Cross Medical Science), Chorus helicobacter IgG (DIESSE Diagnostica Senese) and Vidas H. pylori IgG (bioMérieux). Positive UBT findings were obtained in 40.6% of included subjects. The sensitivities and the specificities of Vidas, Chorus and Genedia were 89.7%, 100% and 100% and 85.5%, 75.4% and 80.7%, respectively. We found no differences in sensitivity between the Vidas and Chorus (P=0.125), Chorus and Genedia (P=0.125) and Vidas and Genedia (P=1.000) assays. There were also no differences in specificity between the Vidas and Chorus (P=0.070), Chorus and Genedia (P=0.508) and Vidas and Genedia (P=0.549) assays. In Korean adults, the Genedia H. pylori ELISA, Chorus helicobacter IgG and Vidas ...Continue Reading

Associated Clinical Trials

References

Aug 1, 1991·Journal of Clinical Microbiology·N J TalleyM J Blaser
Oct 1, 1994·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M TrautmannR Marre
Oct 1, 1993·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·A K JensenC H Wachmann
Jul 15, 1997·Statistics in Medicine·N A Obuchowski, D K McClish
Sep 17, 1998·Journal of Clinical Microbiology·R J LaheijA L Verbeek
Jan 19, 2000·The American Journal of Gastroenterology·D O FaigelM B Fennerty
Dec 22, 2007·Journal of Clinical Gastroenterology·André KorstanjeCornelis B H W Lamers
May 21, 2010·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Tae Ho SeoHye Seung Han
Apr 12, 2012·Gut·Peter MalfertheinerUNKNOWN European Helicobacter Study Group
Jan 16, 2013·Helicobacter·Christophe BurucoaJean-Louis Fauchère

❮ Previous
Next ❯

Citations

Sep 16, 2015·Helicobacter·Andreas MentisFrancis Mégraud
Aug 18, 2016·Helicobacter·Francis MégraudPhilippe Lehours
Apr 6, 2017·Journal of Korean Medical Science·Sang Pyo LeeChan Sup Shim
Mar 16, 2018·The Cochrane Database of Systematic Reviews·Lawrence Mj BestKurinchi Selvan Gurusamy
Aug 31, 2016·World Journal of Gastrointestinal Pathophysiology·Hyun Ah ChungHye Seung Han
Jun 29, 2018·Journal of Pathogens·Amin Talebi Bezmin Abadi
Apr 12, 2019·Gut and Liver·Hyungyung KwonChan Sup Shim
Oct 25, 2017·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Ji Hye KimChan Sup Shim
Jan 22, 2021·Clinical Endoscopy·Sun-Young Lee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre
Nan-Jing PengPing-I Hsu
Nihon rinsho. Japanese journal of clinical medicine
K NishikawaMasahiro Asaka
© 2022 Meta ULC. All rights reserved