Validation of WINROP for detecting retinopathy of prematurity in a North American cohort of preterm infants

Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
Jennifer L JungAnne Lynch

Abstract

WINROP (weight, insulin-like growth factor 1, neonatal, retinopathy of prematurity) is a web-based retinopathy of prematurity (ROP) risk algorithm that uses postnatal weight gain as a surrogate of insulin-like growth factor-1 (IGF-1) to predict the risk of severe ROP in premature infants. The purpose of this study was to validate the web-based algorithm WINROP in detecting severe (type 1 or type 2) ROP in a North American cohort of infants. The records of consecutive infants who underwent ROP examinations between 2008 and 2011 were reviewed retrospectively. Infants were classified into categories of "alarm" (at risk for developing severe ROP) and "no alarm" (minimal risk for severe ROP). A total of 483 were included. Alarm occurred in 241 neonates (50%), with the median time from birth to alarm of 2 weeks. WINROP had a sensitivity of 81.8% (95% CI, 67.3%-91.8%) and specificity of 53.3% (95% CI, 48.5%-58.0%) for identifying infants with severe ROP. Eight of the 44 infants with severe ROP were not detected (5 with type 1 and 3 with type 2). Of these 8 infants, 7 (88%) had birth weight in excess of the 70th pecentile. With additional weight data entry, sensitivity of WINROP rose to 88.6%. Very preterm infants (gestational age of ≤...Continue Reading

References

May 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·A HellstromL E Smith
Dec 10, 2003·Archives of Ophthalmology·UNKNOWN Early Treatment For Retinopathy Of Prematurity Cooperative Group
Jul 13, 2005·Archives of Ophthalmology·UNKNOWN International Committee for the Classification of Retinopathy of Prematurity
Jan 21, 2010·Acta Paediatrica·A Pérez-MuñuzuriJ M Fraga-Bermúdez
Apr 14, 2010·Archives of Ophthalmology·Carolyn WuLois E H Smith
Jun 5, 2012·Biochimica Et Biophysica Acta·Tiago Ferreira da SilvaPedro Brites
Jul 18, 2012·Archives of Ophthalmology·Luz Consuelo Zepeda-RomeroAnn Hellström
Jan 2, 2013·Pediatrics·Walter M FiersonUNKNOWN American Association of Certified Orthoptists
Aug 30, 2013·Archives of Disease in Childhood. Fetal and Neonatal Edition·Chinthika PiyasenaBrian W Fleck
Feb 27, 2014·The British Journal of Ophthalmology·Laila ErikssonAnn Hellström
Jun 11, 2014·American Journal of Perinatology·Chia-Hung KoMei-Yung Chung
Jun 21, 2016·Acta Ophthalmologica·Stefano PiermarocchiPaola Lago
Nov 5, 2016·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Nurullah KoçakNursen Ariturk

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Citations

Jul 25, 2017·Pediatric Research·Christoph BührerJanet Berrington
Jul 4, 2019·JAMA Ophthalmology·Stanford TaylorUNKNOWN Imaging and Informatics in Retinopathy of Prematurity Consortium
Sep 8, 2020·Ophthalmic Epidemiology·Lauren C MehnerAnne M Lynch
Jan 1, 2021·Frontiers in Pediatrics·Alejandro Pérez-MuñuzuriMaría Luz Couce
Mar 30, 2021·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Ana C AlmeidaSusana Teixeira

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