Validation of WINROP (online prediction model) to identify severe retinopathy of prematurity (ROP) in an Australian preterm population: a retrospective study.

Eye
Saumil DesaiGeoffrey C Lam

Abstract

Retinopathy of prematurity (ROP) is the most common disease leading to blindness in extreme preterm infants. Current screening guidelines recommend frequent eye examinations. There is a dearth of trained ophthalmologists for these frequent screening procedures. The ANZNN neonatal network report (2013) found that only 6.4% of all screened infants had severe ROP and less than half received treatment. WINROP (online prediction model, Sweden) uses the postnatal weight gain (surrogate marker for low insulin-like growth factor IGF-1 and poor retinal vascular growth) to identify ROP requiring treatment and aims to reduce the number of examinations. Our objective was to validate the WINROP model in an Australian cohort of preterm infants. Birth weight, gestational age, and weekly weight measurements were retrieved retrospectively along with the final ROP outcomes and plotted on the online WINROP software. The sensitivity, specificity, positive predictive value, and negative predictive value of WINROP were 85.7%, 59.0%, 6.98%, and 99.1% respectively for a cohort of 221 preterm infants (Median birth weight, 1040 g; Gestational age, 27.9 weeks). WINROP alarm was signaled in 42.6% of all infants. WINROP did not signal an alarm in one infan...Continue Reading

References

Mar 20, 2001·Archives of Pediatrics & Adolescent Medicine·S K LeeUNKNOWN Canadian Neonatal Network
May 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·A HellstromL E Smith
Mar 27, 2002·Eye·L HainesUNKNOWN Royal College of Paediatrics and Child Health, the Royal College of Ophthalmologists and British Association of Perinatal Me
Dec 10, 2003·Archives of Ophthalmology·UNKNOWN Early Treatment For Retinopathy Of Prematurity Cooperative Group
Jul 13, 2005·Archives of Ophthalmology·UNKNOWN International Committee for the Classification of Retinopathy of Prematurity
Apr 14, 2010·Archives of Ophthalmology·Carolyn WuLois E H Smith
Jul 18, 2012·Archives of Ophthalmology·Luz Consuelo Zepeda-RomeroAnn Hellström
Aug 30, 2013·Archives of Disease in Childhood. Fetal and Neonatal Edition·Chinthika PiyasenaBrian W Fleck
Mar 11, 2015·Journal of Paediatrics and Child Health·Brian A Darlow
Apr 19, 2016·Neonatology·Luz Consuelo Zepeda-RomeroAnn Hellström

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Citations

Mar 30, 2021·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Ana C AlmeidaSusana Teixeira

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Software Mentioned

WINROP
SPSS

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