Validation study of the s classification for melanoma patients with positive sentinel nodes: the Montreal experience

Annals of Surgical Oncology
Rami YounanS Meterissian

Abstract

Standard of care is to perform a complete lymph node dissection (CLND) in melanoma patients with positive sentinel lymph nodes (SLNs). However, less than 20% will have metastases in non-SLNs. The S classification was described to predict the non-SLN status, hoping to identify a subset of patients who can be spared the CLND. We tried to validate the feasibility and usefulness of this classification. We performed a retrospective chart review. All melanoma cases between 1996 and 2006 were included, and 359 patients with SLN biopsies were identified. All pathology slides were reviewed with an emphasis on the S classification. There were 365 SLN biopsies performed. A total of 82 patients (22.8%) had positive SLNs, while 277 patients (77.2%) had negative SLNs. There were 22 patients classified as SI, 18 as SII, 37 as SIII, and 5 were unclassified. On CLND, only 10 patients (12.2%) had positive non-SLNs. None of these were classified as SI while 2 patients (11%) were classified as SII and 8 (22%) as SIII. The S category was found to be a predictor of non-SLN status, and this reached statistical significance (P = 0.044). On univariate analysis, only an increasing Breslow depth and ulceration were predictive of a non-SI status. Our resu...Continue Reading

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Citations

Sep 26, 2013·The American Journal of Surgical Pathology·Richard A ScolyerUNKNOWN International Collaboration on Cancer Reporting
Apr 11, 2013·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·V Nagaraja, G D Eslick
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Nov 10, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hans StarzLutz Kretschmer
Sep 9, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rajmohan MuraliRichard A Scolyer
Mar 18, 2011·Annals of Surgery·Rajmohan MuraliRichard A Scolyer
Dec 29, 2020·The Journal of Surgical Research·Arezoo RajaeeMichael E Egger

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