Validity and generalizability of findings of randomized controlled trials on arthroscopic partial meniscectomy of the knee

Scandinavian Journal of Medicine & Science in Sports
A Malmivaara

Abstract

The validity and generalizability of evidence from trials on arthroscopic partial meniscectomy (APM) for a ruptured meniscus of the knee has been debated in scientific journals. The aim of this paper was to assess the validity and generalizability of evidence for trials on effectiveness of APM by a novel Benchmarking method; to compare this assessment with established assessment methods; and to make an overall assessment of the current evidence on validity and generalizability of findings. Literature search was undertaken to find all randomized controlled trials. The benchmarking method, the Cochrane method for the assessment of validity of RCTs, and CONSORT method for the assessment of generalizability of findings were used. The data were extracted and checked for accuracy twice. Seven RCTs were found, of which 2 were double blinded. The benchmarking method indicated that only one trial, assessing real-world effectiveness, had recruited patients comprehensively from the catchment area and showed clinically important effectiveness for APM. All trials had deficiencies in reporting of baseline characteristics and adherence to interventions. In 5 trials, the crossover to surgery from conservative treatment arm was between 19 and 3...Continue Reading

References

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Citations

Apr 17, 2019·European Journal of Physical and Rehabilitation Medicine·William M LevackStefano Negrini
Jan 25, 2020·American Journal of Physical Medicine & Rehabilitation·Antti MalmivaaraJari Arokoski
Sep 22, 2020·Orthopaedic Journal of Sports Medicine·Jason B SmoakLeslie J Bisson
Nov 25, 2020·Scandinavian Journal of Medicine & Science in Sports·Michael R KrogsgaardJonathan D Comins

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