Validity of expert assigned retrospective estimates of occupational polychlorinated biphenyl exposure

The Annals of Occupational Hygiene
Curt T DellaValleMelissa C Friesen

Abstract

Assessment of retrospective exposures based on expert judgment in case-control studies is usually of unknown validity because of the difficulty in finding gold standards for comparison. We investigated the relationship between expert-assigned retrospective occupational polychlorinated biphenyl (PCB) exposure estimates and serum PCB concentrations. Analyses were conducted on a subset of cases (n = 94) and controls (n = 96) in the multi-center National Cancer Institute, Surveillance, Epidemiology, and End Results Case-Control Study of non-Hodgkin lymphoma. Based on the subjects' lifetime work histories, an industrial hygienist assigned each job a probability of PCB exposure [<5% (unexposed), 5-<50% (possibly exposed), ≥50% (probably exposed)]. Ordinary least squares regression was used to investigate associations between the probability rating and log-transformed lipid-adjusted serum levels of 14 PCB congeners and total PCBs (ΓPCBs). Compared to unexposed participants (n = 163), those with a probably exposed job (n = 7) had serum levels that were 87% higher for ΓPCBs (95% confidence interval: 1.33-2.62) and 38% of serum level variability was explained by the probability rating. Statistically significant associations between proba...Continue Reading

References

Aug 17, 1999·Occupational and Environmental Medicine·E TielemansK Hartog
Dec 8, 2004·Environmental Health Perspectives·Jay H LubinPatricia Hartge
Jun 14, 2005·Epidemiology·Joanne S ColtPatricia Hartge
Dec 3, 2005·Cancer Research·Anneclaire J De RoosNathaniel Rothman
Jul 26, 2007·Archives of Environmental & Occupational Health·Ruth H AllenPatricia Stewart
Oct 16, 2007·Journal of Toxicology and Environmental Health. Part a·B R NicholsJ C Lamb
Mar 11, 2010·Journal of Exposure Science & Environmental Epidemiology·Richard F SeegalRobert J McCaffrey
Mar 4, 2011·Environmental Health Perspectives·Mark P PurdueJoanne S Colt
Mar 19, 2013·The Lancet Oncology·Béatrice Lauby-SecretanUNKNOWN WHO International Agency for Research on Cancer
Aug 21, 2013·Environmental Science & Technology·Curt T DellaValleMary H Ward
Apr 17, 2014·Journal of Exposure Science & Environmental Epidemiology·Yu-Cheng ChenMelissa C Friesen

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Citations

Jul 13, 2019·Current Environmental Health Reports·Jean-François Sauvé, Melissa C Friesen
Jul 17, 2019·Occupational and Environmental Medicine·Jean-François SauvéMelissa C Friesen

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