PMID: 1197580Oct 14, 1975Paper

Validity of head-dipping as a measure of exploration in a modified hole-board

Psychopharmacologia
S E File, A G Wardill

Abstract

To determine whether head-dipping could be validated as a measure of exploration a modified hole-board was developed with four holes in the floor, under which novel objects could be placed. Two criteria for considering head-dipping as a measure of exploration were proposed: firstly that it should reflect novel aspects of the environment; secondly, that exposure to the hole-board should result in information storage. That head-dipping reflected novelty was indicated by the longer duration of head-dips on initial exposure if objects were present, and also on a second exposure when objects were introduced for the first time. Information storage was indicated by habituation on re-exposure to the hole-board. A significant positive correlation between head-dipping in the "four" and "sixteen" hole-boards was obtained for rats, but not for mice. This provided some indirect evidence that rat head-dipping in the "sixteen hole-board" also reflects exploration. (+)Amphetamine and alcohol were tested in the modified hole-board, and (+)amphetamine decreased and alcohol increased the frequency and duration of head-dips.

References

Jan 1, 1971·Psychopharmacologia·L Valzelli
May 1, 1973·Animal Behaviour·J Archer
Jan 1, 1973·Psychopharmacologia·N A Nolan, M W Parkes
May 14, 1971·Nature·M DorrA Summerfield
Jan 1, 1972·Psychopharmacologia·R N Hughes
Jan 1, 1969·Psychopharmacologia·J H van Abeelen, H Strijbosch
Jun 1, 1965·Canadian Journal of Psychology·R E WIMER, J L FULLER

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Citations

Jan 1, 1978·Developmental Psychobiology·S E File
May 1, 1978·Developmental Psychobiology·J WeinbergS Levine
Jul 1, 1978·Developmental Psychobiology·S E File
Sep 1, 1978·Developmental Psychobiology·S E File
Aug 8, 2002·Phytotherapy Research : PTR·A L da SilvaE Elisabetsky
May 9, 1977·Psychopharmacology·R O MakanjuolaG W Ashcroft
Jan 1, 1983·Psychopharmacology·R G ListerD J Greenblatt
Jan 1, 1982·Psychopharmacology·L M Adams, M A Geyer
Jan 1, 1980·Psychopharmacology·S E File
Jan 1, 1981·Psychopharmacology·R Misslin, P Ropartz
Jan 1, 1982·Psychopharmacology·G Bammer, G B Chesher
Sep 1, 1979·Psychopharmacology·M A GeyerR L Hawkins
Jun 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·S E File
Mar 1, 1993·Behavior Genetics·R Plomin, G E McClearn
Jul 6, 2000·Journal of Physiology and Biochemistry·R Hernández-TristánM L Leret

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