PMID: 1182967Dec 1, 1975Paper

Validity of myocardial infarction models.

Circulation
H A Fozzard

Abstract

Because of the importance of acute myocardial infarction, much effort has been made to develop a representative animal model. Clinical characteristics that have been sought in the models include sudden death, early and late tachyarrhythmias, slow cardiac rhythms and bundle blocks, and variable influence of location of infarction. Each of these characteristics has been found under some conditions and in some models, but it has not been possible to imitate the entire range of the human disease in a simple model. Each model has significant drawbacks in terms of nonhuman cardiac response to stress or drugs, different coronary artery physiology, convenience of study, or cost. In particular, the use of isolated tissue confuses the influences of hypoxia and ischemia. The models have been of great value to investigation in myocardial infarction, but more focus on physiological and biochemical mechanisms may help to avoid the errors inherent in the use of models.

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Related Papers

Developments in Ophthalmology
Stefan SchraderGerd Geerling
European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
Gürkan CetinKadir Babaoğlu
Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
Yanliang WangDelin Lei
Wiadomości lekarskie : organ Polskiego Towarzystwa Lekarskiego
Beata MarniokRobert Jarosz
© 2022 Meta ULC. All rights reserved