Validity of new methods to evaluate renal function in cancer patients treated with cisplatin

Cancer Chemotherapy and Pharmacology
Yohei FunakoshiHironobu Minami

Abstract

Creatinine clearance (Ccr) is used as a marker of renal function in cancer chemotherapy, but it is not correlated with glomerular filtration rate (GFR) after high-dose cisplatin treatment. In addition to Ccr, measured using 24-h urine collection (24-h Ccr) or Cockcroft-Gault formula (CGF), the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation and the Japanese GFR estimation equation (the Japanese equation) have been recently developed to estimate GFR for predicting renal function. However, these equations remain to be evaluated, particularly in cancer patients treated with cisplatin. Therefore, we investigated the validity of these equations for predicting the GFR in cancer patients treated with cisplatin. GFR was measured by inulin clearance (Cin) in 50 cancer patients and compared with GFR estimated by the CKD-EPI equation, the Japanese equation, and Ccr estimated by CGF or measured by 24-h Ccr before the first and third cisplatin-containing chemotherapy cycles (considered pretreatment and posttreatment, respectively). Before treatment, the CKD-EPI and the Japanese equations estimated GFR with higher accuracy than Ccr. Posttreatment bias values for GFR estimation using the CKD-EPI and the Japanese equations...Continue Reading

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Citations

Mar 21, 2017·Scandinavian Journal of Clinical and Laboratory Investigation·Lotte LindbergBo Zerahn
Jul 10, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Laura CosmaiMaurizio Gallieni
Dec 5, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ben SprangersMark A Perazella
Jan 1, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jolanta MalyszkoJacek Malyszko
May 4, 2020·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Ben SprangersKenar D Jhaveri

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Methods Mentioned

BETA
urine collection

Software Mentioned

SPSS Statistics

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