Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins

Diabetes Care
M R ChristieA G Ziegler

Abstract

To determine whether screening for the presence of multiple antibody markers for IDDM is effective at identifying individuals with high risk for disease development. Antibodies to GAD and the tyrosine phosphatase-like protein 1A-2 were determined in sequential serum samples from 44 first-degree relatives of IDDM patients, identified as possessing islet cell antibody (ICA) and/or insulin autoantibody (IAA), who were followed prospectively for IDDM development, ICA, IAA, and antibodies to GAD and 1A-2 were also determined in 93 cases of new-onset nonfamilial IDDM. The presence of two or more antibodies in addition to ICA or IAA conferred high risk (61%) for development of IDDM within 5 years of entry into the study and identified 89% of those who have developed IDDM on current follow-up. None of the relatives positive for ICA or IAA alone, in the absence of other antibody markers, have developed IDDM. Antibodies to islet antigens could both appear and disappear in follow-up samples obtained after entry into the study. The majority (60%) of young (< 16 years), sporadic cases of IDDM had multiple antibodies to islet antigens, but this proportion was lower in older patients (37%). A screening strategy based on the analysis of antibo...Continue Reading

Citations

Mar 29, 2002·Diabetes/metabolism Research and Reviews·C HendrieckxC Bradley
Nov 5, 1997·Diabetologia·H NoorchashmL C Harrison
Aug 21, 2013·Diabetologia·Carolyn C RichardsonMichael R Christie
Mar 5, 2003·Diabetes Technology & Therapeutics·William E WinterDesmond Schatz
Oct 25, 2002·Journal of Women's Health & Gender-based Medicine·Judith Luborsky
Jan 3, 2001·Pediatric Research·A Toivonen The Childhood Diabetes In Finl
Sep 5, 2013·Autoimmunity·Carolyn C RichardsonMichael R Christie
Jun 14, 2015·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Kerry A McLaughlinMichael R Christie
May 17, 2005·Diabetes/metabolism Research and Reviews·Bernd FrankeTerry J Wilkin
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Jan 5, 2006·Pediatric Diabetes·Desmond A Schatz, Mark A Atkinson
Mar 1, 2002·Journal of Autoimmunity·Ivana Durinovic-BellóAnette-G Ziegler
Jun 28, 2002·Diabetes Care·Michael R ChristieUNKNOWN Canadian-European Randomised Control Trial Group
Jul 9, 2002·Journal of Pediatric Endocrinology & Metabolism : JPEM·Maria E R da SilvaAna C Golberg
Apr 22, 2020·Medical Microbiology and Immunology·Kerry A McLaughlinMichael R Christie
Sep 17, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kerry A McLaughlinMichael R Christie
Feb 20, 2004·Acta Paediatrica·S MrenaUNKNOWN Childhood Diabetes in Finland Study Group

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