Validity of serum creatine kinase as a measure of muscle injury produced by lumbar surgery

Journal of Spinal Disorders & Techniques
Dinesh KumbhareBrett Dunlop

Abstract

Serum creatine kinase (CK) concentrations have historically been used to investigate muscle disease and serious muscle damage, and there is a growing interest in the potential for a biochemical approach to quantifying skeletal muscle injury occurring in orthopedic surgeries and spinal injuries. The wide availability of CK measurement could foster spinal muscle injury research. However, measurement validity has never been systematically demonstrated in clinical settings. In this study, the validity of serum CK concentration elevation as an index of muscle injury was investigated using lumbar decompression surgery (LDS) as a model. Blood samples were obtained from 18 research volunteers drawn from the clinical population undergoing LDS. A baseline sample was taken in the preoperative waiting area. Each subject's highest CK concentration between 12 and 48 hours after surgery was used as the biochemical injury response. The surface area of muscle isolated (incision lengthxdepth) and strained by retraction was obtained for concurrent validity testing against biochemical measurement. The correlation between highest total CK concentration and muscle surface area was moderate (r=0.60) and significant (P<0.01). Correlations between surf...Continue Reading

References

Aug 1, 1992·International Journal of Sports Medicine·K Nosaka, P M Clarkson
Feb 1, 1992·Journal of Applied Physiology·J MairB Puschendorf
May 1, 1992·Medicine and Science in Sports and Exercise·P M ClarksonB Braun
Jan 1, 1989·Spine·L Janssen, R R Hansebout
Jan 1, 1986·European Journal of Applied Physiology and Occupational Physiology·D J NewhamR H Edwards
Jul 1, 1987·Sports Medicine·T D Noakes
Dec 1, 1987·Medicine and Science in Sports and Exercise·J A SchwaneJ H Sloan
Jan 1, 1986·European Journal of Applied Physiology and Occupational Physiology·J P KirwanW C Byrnes
Jul 31, 1974·Clinica Chimica Acta; International Journal of Clinical Chemistry·H Y Meltzer, P A Holy
Jun 1, 1971·Clinica Chimica Acta; International Journal of Clinical Chemistry·H Y Meltzer
Apr 1, 1966·Clinica Chimica Acta; International Journal of Clinical Chemistry·P D Griffiths
Jun 1, 1982·Archives of Internal Medicine·M Liang, A L Komaroff
Jun 1, 1984·American Journal of Public Health·L S Cunningham, J L Kelsey
Jan 1, 1984·Critical Reviews in Clinical Laboratory Sciences·J A Lott, P W Landesman
Aug 1, 1983·International Journal of Sports Medicine·J FridénB Ekblom
Apr 1, 1983·Clinica Chimica Acta; International Journal of Clinical Chemistry·J D SymanskiA J Siegel
Jun 1, 1983·Muscle & Nerve·D J NewhamR H Edwards
Jan 1, 1980·European Journal of Applied Physiology and Occupational Physiology·G Haralambie, L Senser
Apr 1, 1994·International Journal of Sports Medicine·H Kuipers
Jun 1, 1993·Journal of Applied Physiology·J B RodenburgR W De Boer
Jun 27, 1997·Clinica Chimica Acta; International Journal of Clinical Chemistry·S SorichterB Puschendorf
Dec 10, 1997·International Journal of Sports Medicine·P M Clarkson
Aug 12, 1998·Acta Anaesthesiologica Scandinavica·P Hobisch-HagenJ Mair
Aug 18, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·A S Jaffe
Aug 19, 1999·The Journal of Trauma·W StreckerL Kinzl
Mar 22, 2000·Clinical Chemistry and Laboratory Medicine : CCLM·F S Apple
Apr 6, 2001·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·G N OnuohaB Pau
Sep 15, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·M Plebani
May 7, 2002·Journal of Strength and Conditioning Research·Kazunori Nosaka, Mike Newton
Aug 15, 2002·Journal of Spinal Disorders & Techniques·Jun TakahashiKunio Takaoka
Aug 24, 2002·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·S Scott, P L Sanderson
Sep 7, 2002·Cardiology in Review·Beth R Malasky, Joseph S Alpert
Apr 12, 2003·International Journal of Epidemiology·Sarah ClarkRory Collins
Nov 25, 2003·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·M MuñozC Sebastián
May 25, 2006·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Satoru DemuraKatsuro Tomita
Aug 25, 2007·Clinical and Investigative Medicine. Médecine Clinique Et Experimentale·Dinesh KumbhareJonathan Adachi

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Citations

Jul 11, 2008·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Rob D DickermanCecilio Alvarado
Mar 9, 2011·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Sven Rainer KantelhardtVeit Rohde
Mar 23, 2011·Journal of Neurosurgery. Spine·Elias DakwarJuan S Uribe
Jun 13, 2009·The Journal of Orthopaedic and Sports Physical Therapy·Joy C MacDermidUNKNOWN HaNSA (Head and Neck Shoulder and Arm Research Group)
Apr 25, 2012·Wiener klinische Wochenschrift·Florian M KovarOswald F Wagner
Apr 1, 2013·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·A SousaR Pinto
Aug 2, 2011·The Spine Journal : Official Journal of the North American Spine Society·Jason C Eck
Dec 29, 2009·Journal of Hand Therapy : Official Journal of the American Society of Hand Therapists·Catherine C Goodman
Apr 21, 2009·Clinical Biochemistry·O A Al-MosalemL Al-Ayadhi
Jun 13, 2009·The Journal of Surgical Research·Dinesh KumbhareJonathan Adachi
May 3, 2014·Orthopaedics & Traumatology, Surgery & Research : OTSR·M TinelliA J Suda
Dec 24, 2019·Expert Review of Medical Devices·Yong Ahn
May 29, 2016·Clinical Orthopaedics and Related Research·Kirsten L Poehling-MonaghanMark W Pagnano
Dec 9, 2020·Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy·Katsuhiko MaezawaYuichiro Maruyama

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